Journal article
IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
The Journal of immunology (1950), v 180(1), pp 350-360
01 Jan 2008
PMID: 18097036
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this study, we examined the effect of in vivo treatment of acutely SIV-infected Mamu-A*01+ rhesus macaques with IL-15. IL-15 treatment during acute infection increased viral set point by 3 logs and accelerated the development of simian AIDS in two of six animals with one developing early minimal lesion SIV meningoencephalitis. Although IL-15 induced a 2- to 3-fold increase in SIV-specific CD8+ T cell and NK cell numbers at peak viremia and reduced lymph node (LN) SIV-infected cells, this had no impact on peak viremia and did not lower viral set point. At viral set point, however, activated SIV-specific CD8+ T cells and NK cells were reduced in the blood of IL-15-treated animals and LN SIV-infected cells were increased. Week 30 LN from IL-15-treated animals had significantly increased Gag-specific CD8+ T cell numbers, whereas total cell, lymphocyte, and CD4+ T cell numbers were reduced. IL-15 treatment significantly reduced anti-SIV Ab concentrations at week 3 and viral set point. IL-15 increased Ki-67+CD4+ T cells at week 1 of treatment and reduced blood CCR5+ and CD45RA-CD62L- CD4+ T cells. The frequency of day 7 Ki-67+CD4+ T cells strongly correlated with viral set point. These findings suggest that CD4+ T cell activation during acute infection determines subsequent viral set point and IL-15 treatment by increasing such activation elevates viral set point. Finally, IL-15-treated acutely SIV-infected primates may serve as a useful model to investigate the poorly understood mechanisms that control viral set point and disease progression in HIV infection.
Metrics
Details
- Title
- IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
- Creators
- Yvonne M Mueller - Department of Microbiology and Immunology, and Center for Immunology and Vaccine Science, Drexel University College of Medicine, Philadelphia, PA 19129, USADuc H DoSusan R AltorkCarol M ArtlettEdward J GracelyChristos D KatsetosAgustin LegidoFrancois VillingerJohn D AltmanCharles R BrownMark G LewisPeter D Katsikis
- Publication Details
- The Journal of immunology (1950), v 180(1), pp 350-360
- Publisher
- American Association of Immunologists (AAI); United States
- Grant note
- AI62437 / NIAID NIH HHS R01 AI046719-09 / NIAID NIH HHS R01 AI046719 / NIAID NIH HHS R01 AI062437-03 / NIAID NIH HHS R01 AI062437 / NIAID NIH HHS R01 AI052005 / NIAID NIH HHS AI52005 / NIAID NIH HHS R01 AI46719 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Microbiology and Immunology
- Web of Science ID
- WOS:000252162700042
- Scopus ID
- 2-s2.0-40449100795
- Other Identifier
- 991014878358904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology