Journal article
IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells
International immunology, v 18(6), pp 827-835
12 Apr 2006
PMID: 16611649
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
It is now well established that the cytokine environment influences the activation, differentiation, proliferation and death of T lymphocytes during the primary response to antigen. Using an in vitro model, we investigated the influence of IL-4, added at the onset of TCR stimulation, on phenotypic and functional markers of naive CD8+ T cell activation including the up-regulation of activation markers, proliferation as well as the susceptibility to activation-induced cell death (AICD). We report that IL-4, unlike IL-2 added at the onset of repeated TCR stimulation of naive CD8+ T cells prevents AICD, in part due to its ability to maintain the level of the survival-related protein Bcl-2. Moreover, TCR-triggered activation of naive CD8+ T cells in the presence of IL-4 leads to the development of a CD8+ T cell subset that proliferates normally, but which fails to exhibit characteristic activation parameters such as the up-regulation of CD25 and Granzyme B. Taken together, these results demonstrate that exposure to IL-4 during primary activation influences CD8+ T cell differentiation by inducing the development of a sub-population of AICD-resistant, proliferation-competent cells that do not show some of the typical features of CD8+ T cell activation.
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Details
- Title
- IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells
- Creators
- Catherine Riou - Hôpital Saint-LucAlain R Dumont - Hôpital Saint-LucBader Yassine-Diab - Hôpital Saint-LucElias K HaddadRafick-Pierre Sekaly - E-mail: rafick-pierre.sekaly@umontreal.ca
- Publication Details
- International immunology, v 18(6), pp 827-835
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000238769400001
- Scopus ID
- 2-s2.0-33745607909
- Other Identifier
- 991020099185104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology