Journal article
IL-7 is a potent and proviral strain–specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
The Journal of clinical investigation, v 115(1), pp 128-137
01 Jan 2005
PMID: 15630452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The persistence of HIV-1 in virally suppressed infected individuals on highly active antiretroviral therapy (HAART) remains a major therapeutic problem. The use of cytokines has been envisioned as an additional therapeutic strategy to stimulate latent proviruses in these individuals. Immune activation therapy using IL-2 has shown some promise. In the present study, we found that IL-7 was significantly more effective at enhancing HIV-1 proviral reactivation than either IL-2 alone or IL-2 combined with phytohemagglutinin (PHA) in CD8-depleted PBMCs. IL-7 also showed a positive trend for inducing proviral reactivation from resting CD4+ T lymphocytes from HIV-1–infected patients on suppressive HAART. Moreover, the phylogenetic analyses of viral envelope gp120 genes from induced viruses indicated that distinct proviral quasispecies had been activated by IL-7, as compared with those activated by the PHA/IL-2 treatment. These studies thus demonstrate that different activators of proviral latency may perturb and potentially deplete only selected, specific portions of the proviral archive in virally suppressed individuals. The known immunomodulatory effects of IL-7 could be combined with its ability to stimulate HIV-1 replication from resting CD4+ T lymphocytes, in addition to other moieties, to potentially deplete HIV-1 reservoirs and lead to the rational design of immune-antiretroviral approaches.
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Details
- Title
- IL-7 is a potent and proviral strain–specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
- Creators
- Feng-Xiang Wang - Thomas Jefferson UniversityYan Xu - Thomas Jefferson UniversityJulie Sullivan - Thomas Jefferson UniversityEmily Souder - Drexel University, PediatricsElias G. Argyris - Thomas Jefferson UniversityEdward A. Acheampong - Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Area de Patogenia Viral, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain. University of Pennsylvania, Division of Infectious Diseases, Philadelphia, Pennsylvania, USAJaime Fisher - Thomas Jefferson UniversityMaria Sierra - Centro Nacional de MicrobiologiaMichael M. Thomson - Centro Nacional de MicrobiologiaRafael Najera - Centro Nacional de MicrobiologiaIan Frank - University of PennsylvaniaJoseph Kulkosky - Chestnut Hill CollegeRoger J. Pomerantz - Thomas Jefferson UniversityGiuseppe Nunnari - Thomas Jefferson University
- Publication Details
- The Journal of clinical investigation, v 115(1), pp 128-137
- Publisher
- American Society for Clinical Investigation
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000226509000021
- Scopus ID
- 2-s2.0-13744259064
- Other Identifier
- 991021838155804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental