Journal article
IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection
The Journal of immunology (1950), v 183(11), pp 7006-7013
01 Dec 2009
PMID: 19915054
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
IL-9 is a cytokine of great current interest associated with allergic/Th2 responses. High levels of IL-9 are present in bronchial secretions from infants with respiratory syncytial virus (RSV) bronchiolitis. To test its effects in RSV disease with a Th2 profile, BALB/c mice were vaccinated with recombinant vaccinia virus expressing the RSV G protein. On RSV challenge, immunized mice developed augmented disease characterized by enhanced pulmonary Th2 and local IL-9 production peaking on days 7-10 of RSV infection. Depletion with anti-IL-9 Ab at vaccination or RSV challenge enhanced viral clearance. Depletion only at challenge had no effect on disease severity, whereas depletion at immunization and challenge enhanced Th1 responses, inhibited virus-specific IgG1 production, and enhanced disease severity. By contrast, depletion of IL-9 at immunization boosted IgG2a and inhibited the Th2 response and disease during subsequent infection without a concomitant increase in type 1 cytokines. Adoptive transfer of secondary memory CD4 T cells from the spleens of IL-9-depleted mice into naive recipients replicated many of the effects of depletion, indicating that IL-9 acts via CD4 T cells. Therefore, IL-9 is a previously unknown but key modulator of antiviral immunity, regulating T and B cell responses and having potent and specific effects on viral lung disease.
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Details
- Title
- IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection
- Creators
- Jonathan S Dodd - Imperial College LondonEda Lum - Imperial College LondonJohn Goulding - Imperial College LondonRoshell Muir - Imperial College LondonJacques Van Snick - UCLouvainPeter J M Openshaw
- Publication Details
- The Journal of immunology (1950), v 183(11), pp 7006-7013
- Publisher
- American Association of Immunologists (AAI)
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000272478800019
- Scopus ID
- 2-s2.0-73349114622
- Other Identifier
- 991021944124804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology