Journal article
IL‐15 enhances the function and inhibits CD95/Fas‐induced apoptosis of human CD4+ and CD8+ effector‐memory T cells
International immunology, v 15(1)
Jan 2003
PMID: 12502725
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although the effect of IL‐15 has been described on murine cells in vitro and in vivo, its effect on human memory CD8+ T cells is not well characterized. We show here that IL‐15 preferentially enhances the activation and effector function of human effector‐memory CD45RA–CD62L– and CD45RA+CD62L– CD4+ and CD8+ T cells in both healthy and HIV‐infected individuals. We find that IL‐15 increases 2‐ to 5‐fold both the activation and secretion of the effector cytokines IFN‐γ and tumor necrosis factor (TNF)‐α by anti‐CD3‐stimulated purified CD4+ and CD8+ T cells and peripheral blood mononuclear cells from healthy and HIV‐infected individuals. Furthermore, IL‐15 potently inhibits CD95/Fas‐induced apoptosis of the effector‐memory CD4+ and CD8+ T cells from HIV‐infected individuals. These findings suggest that in addition to being a growth and survival factor for memory CD8+ T cells, IL‐15 is also a potent activator of human effector‐memory CD8+ T cells both in healthy and in HIV‐infected individuals.
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Details
- Title
- IL‐15 enhances the function and inhibits CD95/Fas‐induced apoptosis of human CD4+ and CD8+ effector‐memory T cells
- Creators
- Yvonne M. Mueller - Drexel UniversityVera Makar - Microbiology and Immunology, andPaul M. Bojczuk - Microbiology and Immunology, andJames Witek - Medicine, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USAPeter D. Katsikis - Microbiology and Immunology, and
- Publication Details
- International immunology, v 15(1)
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000180693200006
- Scopus ID
- 2-s2.0-0037253892
- Other Identifier
- 991019348760104721
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- Web of Science research areas
- Immunology