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INTERVERTEBRAL DISC DEGENERATION AND REGENERATION: A MOTION SEGMENT PERSPECTIVE
Journal article   Open access   Peer reviewed

INTERVERTEBRAL DISC DEGENERATION AND REGENERATION: A MOTION SEGMENT PERSPECTIVE

EUROPEAN CELLS & MATERIALS, v 41, pp 370-387
Jan 2021
DOI: https://doi.org/10.22203/eCM.v041a24
PMID: 33763848
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.22203/eCM.v041a24View
Published, Version of Record (VoR) Open

Abstract

Back and neck pain have become primary reasons for disability and healthcare spending globally. While the causes of back pain are multifactorial, intervertebral disc degeneration is frequently cited as a primary source of pain. The annulus fibrosus (AF) and nucleus pulposus (NP) subcomponents of the disc are common targets for regenerative therapeutics. However, disc degeneration is also associated with degenerative changes to adjacent spinal tissues, and successful regenerative therapies will likely need to consider and address the pathology of adjacent spinal structures beyond solely the disc subcomponents. This review summarises the current state of knowledge in the field regarding associations between back pain, disc degeneration, and degeneration of the cartilaginous and bony endplates, the AF-vertebral body interface, the facet joints and spinal muscles, in addition to a discussion of regenerative strategies for treating pain and degeneration from a whole motion segment perspective.

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4 Record Views
45 citations in Web of Science
46 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Cell & Tissue Engineering
Engineering, Biomedical
Materials Science, Biomaterials
Orthopedics
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