Journal article
Ice-Templated Scaffolds with Microridged Pores Direct DRG Neurite Growth
Advanced functional materials, v 22(23), pp 4920-4923
05 Dec 2012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Successful spinal cord repair is thought to be promoted with hierarchically structured scaffolds. These should combine aligned porosity with additional linear features on the micrometer scale to guide axons across multiple length scales. Such scaffolds are generated through the carefully controlled directional solidification of an aqueous biopolymer solution, followed by lyophilization. Under specific freezing conditions this yields a highly regular and aligned lamellar architecture. This architecture exhibits uniform ridges of controlled height and width on the lamellar surface. These ridges run parallel to the pore axis, serving as secondary guidance features. The ridges are capable of linearly aligning 62.4% of chick dorsal root ganglia neurites to within +/- 10 degrees of the ridge direction. Notably, neurites sprouting perpendicular to the ridge are guided into alignment with these microridged features.
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Details
- Title
- Ice-Templated Scaffolds with Microridged Pores Direct DRG Neurite Growth
- Creators
- Benjamin W. Riblett - Drexel UniversityNicola L. Francis - Drexel UniversityMargaret A. Wheatley - Drexel UniversityUlrike G. K. Wegst - Dartmouth College
- Publication Details
- Advanced functional materials, v 22(23), pp 4920-4923
- Publisher
- Wiley
- Number of pages
- 4
- Grant note
- Centralized Research Facilities in the College of Engineering at Drexel University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000312300600008
- Scopus ID
- 2-s2.0-84870615660
- Other Identifier
- 991019168429004721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter