Journal article
Identification of Minimal Neuronal Networks Involved in Flexor-Extensor Alternation in the Mammalian Spinal Cord
Neuron (Cambridge, Mass.), v 71(6), pp 1071-1084
22 Sep 2011
PMID: 21943604
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural networks in the spinal cord control two basic features of locomotor movements: rhythm generation and pattern generation. Rhythm generation is generally considered to be dependent on glutamatergic excitatory neurons. Pattern generation involves neural circuits controlling left-right alternation, which has been described in great detail, and flexor-extensor alternation, which remains poorly understood. Here, we use a mouse model in which glutamatergic neurotransmission has been ablated in the locomotor region of the spinal cord. The isolated in vitro spinal cord from these mice produces locomotor-like activity-when stimulated with neuroactive substances-with prominent flexor-extensor alternation. Under these conditions, unlike in control mice, networks of inhibitory interneurons generate the rhythmic activity. In the absence of glutamatergic synaptic transmission, the flexor-extensor alternation appears to be generated by la inhibitory interneurons, which mediate reciprocal inhibition from muscle proprioceptors to antagonist motor neurons. Our study defines a minimal inhibitory network that is needed to produce flexor-extensor alternation during locomotion.
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Details
- Title
- Identification of Minimal Neuronal Networks Involved in Flexor-Extensor Alternation in the Mammalian Spinal Cord
- Creators
- Adolfo E. Talpalar - Karolinska InstitutetToshiaki Endo - Karolinska InstitutetPeter Low - Karolinska InstitutetLotta Borgius - Karolinska InstitutetMartin Hagglund - Karolinska InstitutetKimberly J. Dougherty - Karolinska InstitutetJesper Ryge - Karolinska InstitutetThomas S. Hnasko - University of California, San FranciscoOle Kiehn - Karolinska Institutet
- Publication Details
- Neuron (Cambridge, Mass.), v 71(6), pp 1071-1084
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- Soderberg Foundation Swedish Medical Research Council; Swedish Medical Research Council (SMRC) K01DA026504 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission Karolinska Institutet StratNeuro
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000295556500012
- Scopus ID
- 2-s2.0-80053107449
- Other Identifier
- 991020099619204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences