Journal article
Identification of Novel Regulators of atonal Expression in the Developing Drosophila Retina
Genetics (Austin), v 180(4), pp 2095-2110
Dec 2008
PMID: 18832354
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atonal is a Drosophila proneural protein required for the proper formation of the R8 photoreceptor cell, the founding photoreceptor cell in the developing retina. Proper expression and refinement of the Atonal protein is essential for the proper formation of the Drosophila adult eye. In vertebrates, expression of transcription factors orthologous to Drosophila Atonal (MATH5/Atoh7, XATH5, and ATH5) and their progressive restriction are also involved in specifying the retinal ganglion cell, the founding neural cell type in the mammalian retina. Thus, identifying factors that are involved in regulating the expression of Atonal during development are important to fully understand how retinal neurogenesis is accomplished. We have performed a chemical mutagenesis screen for autosomal dominant enhancers of a loss-of-function
atonal
eye phenotype. We report here the identification of five genes required for proper Atonal expression, three of which are novel regulators of Atonal expression in the Drosophila retina. We characterize the role of the
daughterless
,
kismet
, and
roughened eye
genes on
atonal
transcriptional regulation in the developing retina and show that each gene regulates
atonal
transcription differently within the context of retinal development. Our results provide additional insights into the regulation of Atonal expression in the developing Drosophila retina.
Metrics
Details
- Title
- Identification of Novel Regulators of atonal Expression in the Developing Drosophila Retina
- Creators
- David Melicharek - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104Arpit Shah - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104Ginnene DiStefano - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104Andrew J Gangemi - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104Andrew Orapallo - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104Alysia D Vrailas-Mortimer - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104Daniel R Marenda - Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104
- Publication Details
- Genetics (Austin), v 180(4), pp 2095-2110
- Publisher
- Genetics Society of America
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000262030600025
- Scopus ID
- 2-s2.0-61749104678
- Other Identifier
- 991014877663104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity