Journal article
Identification of a patient with Streptococcus pneumoniae bacteremia and meningitis by the polymerase chain reaction (PCR)
Molecular and cellular probes, Vol.9(3), pp.157-160
Jun 1995
PMID: 7477007
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A polymerase chain reaction (PCR) assay based on the penicillin-binding protein gene PBP2B identified the presence of DNA specific for Streptococcus pneumoniae in the serum and CSF of a patient with culture-proven bacteremia and meningitis. Positive signals were seen to dilutions of 1:125 and 1:390,625 for the blood and CSF specimens, respectively. Potential advantages of PCR over conventional culture include exquisite sensitivity, faster results and the ability to identify the organisms by the presence of species-specific DNA even in patients pretreated with antibiotics.
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Details
- Title
- Identification of a patient with Streptococcus pneumoniae bacteremia and meningitis by the polymerase chain reaction (PCR)
- Creators
- D J Isaacman - Department of Pediatrics, University of Pittsburgh School of Medicine, PA 15213-2583, USAY ZhangJ Rydquist-WhiteR M WadowskyJ C PostG D Ehrlich
- Publication Details
- Molecular and cellular probes, Vol.9(3), pp.157-160
- Publisher
- England
- Grant note
- R01DL02148-01 / PHS HHS 5M01 RR00084 / NCRR NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991014969856804721
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- Biochemical Research Methods
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Cell Biology