Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer
Bioorganic & medicinal chemistry letters, v 26(3), pp 824-828
01 Feb 2016
PMID: 26747394
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key host dependency factors, is an especially appealing region for small molecule targeting. Using a field-based pharmacophore derived from an inhibitor known to interact with this region, coupled to biochemical and biological assessment, we have identified a new compound that inhibits HIV-1 infection and that targets the assembled CA hexamer. (C) 2015 Elsevier Ltd. All rights reserved.
Metrics
Details
- Title
- Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer
- Creators
- Jimmy P. Xu - Drexel UniversityJeffrey D. Branson - Drexel UniversityRae Lawrence - Cresset, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire SG8 0SS, UK.Simon Cocklin - Drexel University
- Publication Details
- Bioorganic & medicinal chemistry letters, v 26(3), pp 824-828
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- R21AI104354 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 1R21AI10435401A1 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000368797600025
- Scopus ID
- 2-s2.0-85020320160
- Other Identifier
- 991019167546304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic