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Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
Identification of human appendicitis by in vitro nuclear magnetic resonance
The Journal of surgical research, v 48(2)
1990
PMID: 2304337
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The spin—lattice relaxation time,
T
1 as determined by nuclear magnetic resonance techniques, correlates positively with tissue water content. The latter relationship has been observed in rabbits with experimentally induced appendicitis whose inflamed appendiceal tissues had significantly higher
T
1's and water contents than tissue from normal controls. The present experiment studied these relationships in humans. Tissue water content and
T
1 were measured on appendiceal tissue from 10 patients with documented appendicitis and from 6 controls without the disease. All
T
1's were determined within 30–60 min of removal of the appendix at operation. The mean
in vitro
T
1 of appendiceal tissue from patients with appendicitis was significantly higher than that of controls (527 ± 15 msec versus 430 ± 17 msec, mean ± SEM,
P < 0.002). In addition, a strong positive correlation was noted between
T
1 and tissue water content (
r = 0.70,
P < 0.01). Based on these findings, the use of
in vivo magnetic resonance imaging techniques to detect human appendicitis noninvasively warrants investigation.
Metrics
Details
- Title
- Identification of human appendicitis by in vitro nuclear magnetic resonance
- Creators
- Danny O. Jacobs - University of PennsylvaniaR.G. Settle - University of PennsylvaniaJohn R. Clarke - University of PennsylvaniaScott O. Trerotola - University of PennsylvaniaA.K. Sachdeva - University of PennsylvaniaGerald L. Wolf - Drexel UniversityJohn L. Rombeau - University of Pennsylvania
- Publication Details
- The Journal of surgical research, v 48(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1990CN59500002
- Scopus ID
- 2-s2.0-0025218372
- Other Identifier
- 991019184293304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery