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Journal article
Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design
Trends in biotechnology (Regular ed.), v 14(10), pp 369-375
1996
PMID: 8987635
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Many cytokines (growth-factor proteins) are constructed from a common four-helix bundle structural framework. Rapid advances have been made in relating the structure and function of a growing number of four-helix bundle cytokines. This understanding opens the way to design
de novo mimetics through such strategies as cytokine hybrids, structure-excerpted scaffolds and contact residue topology mimics. These may provide leads for agonists and antagonists of cell growth and differentiation.
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Details
- Title
- Identifying structure-function relationships in four-helix bundle cytokines: towards de novo mimetics design
- Creators
- Irwin M. Chaiken - University of PennsylvaniaWilliam V. Williams - University of Pennsylvania
- Publication Details
- Trends in biotechnology (Regular ed.), v 14(10), pp 369-375
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Drexel University
- Web of Science ID
- WOS:A1996VN10300004
- Scopus ID
- 2-s2.0-0030272568
- Other Identifier
- 991019520531604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology