If the Kl Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC50 for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?

Journal article

Peer reviewed

Annie Albin Lumen, Poulomi Acharya, Joseph W Polli, Andrew Ayrton, Harma Ellens and Joe Bentz

Drug metabolism and disposition, Vol.38(2), pp.260-269

2010

Additional Links

Biological and medical sciences

Medical sciences

Pharmacology. Drug treatments

1 Record Views

Title: If the Kl Is Defined by the Free Energy of Binding to P-Glycoprotein, Which Kinetic Parameters Define the IC50 for the Madin-Darby Canine Kidney II Cell Line Overexpressing Human Multidrug Resistance 1 Confluent Cell Monolayer?
Creators: Annie Albin Lumen - Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States
Poulomi Acharya - Drexel University
Joseph W Polli - Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKIine, Research Triangle Park, North Carolina, United States
Andrew Ayrton - Preclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKIine, Welwyn, United Kingdom
Harma Ellens - GlaxoSmithKline
Joe Bentz - Drexel University
Publication Details: Drug metabolism and disposition, Vol.38(2), pp.260-269
Publisher: American Society for Pharmacology and Experimental Therapeutics
Resource Type: Journal article
Language: English
Academic Unit: Biology
Identifiers: 991021463537104721