Journal article
IgG Binding Characteristics of Rhesus Macaque FcγR
The Journal of immunology (1950), v 197(7), pp 2936-2947
01 Oct 2016
PMID: 27559046
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Indian rhesus macaques (Macaca mulatta) are routinely used in preclinical studies to evaluate therapeutic Abs and candidate vaccines. The efficacy of these interventions in many cases is known to rely heavily on the ability of Abs to interact with a set of Ab FcγR expressed on innate immune cells. Yet, despite their presumed functional importance, M. mulatta Ab receptors are largely uncharacterized, posing a fundamental limit to ensuring accurate interpretation and translation of results from studies in this model. In this article, we describe the binding characteristics of the most prevalent allotypic variants of M. mulatta FcγR for binding to both human and M. mulatta IgG of varying subclasses. The resulting determination of the affinity, specificity, and glycan sensitivity of these receptors promises to be useful in designing and evaluating studies of candidate vaccines and therapeutic Abs in this key animal model and exposes significant evolutionary divergence between humans and macaques.
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Details
- Title
- IgG Binding Characteristics of Rhesus Macaque FcγR
- Creators
- Ying N Chan - Dartmouth CollegeAustin W Boesch - Dartmouth CollegeNana Y Osei-Owusu - Dartmouth CollegeAli Emileh - Dartmouth CollegeAndrew R Crowley - Dartmouth CollegeSarah L Cocklin - Beth Israel Deaconess Medical CenterSamantha L Finstad - Beth Israel Deaconess Medical CenterCaitlyn H Linde - Beth Israel Deaconess Medical CenterRebecca A Howell - Beth Israel Deaconess Medical CenterIsaac Zentner - Drexel UniversitySimon Cocklin - Drexel UniversityAdam R Miles - CarterraJoshua W Eckman - CarterraGalit Alter - Ragon Institute of MGH, MIT and HarvardJoern E Schmitz - Beth Israel Deaconess Medical CenterMargaret E Ackerman - Dartmouth College
- Publication Details
- The Journal of immunology (1950), v 197(7), pp 2936-2947
- Publisher
- American Association of Immunologists (AAI)
- Grant note
- P01 AI120756 / NIAID NIH HHS R01 AI102691 / NIAID NIH HHS HHSN272201100023C / NIAID NIH HHS R56 AI097315 / NIAID NIH HHS UM1 AI100645 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000385004600042
- Scopus ID
- 2-s2.0-84989873558
- Other Identifier
- 991019167341204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology