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Journal article
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
Nature communications, Vol.15(1), 404
09 Jan 2024
PMID: 38195739
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during human acute viral infection. The analysis of IgM N-glycosylation from healthy controls and hospitalized coronavirus disease 2019 (COVID-19) patients reveals increased high-mannose and sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific immunoglobulin N-glycan profiles. Moreover, the degree of total IgM mannosylation and sialylation correlate significantly with markers of disease severity. We link the changes of IgM N-glycosylation with the expression of Golgi glycosyltransferases. Lastly, we observe antigen-specific IgM antibody-dependent complement deposition is elevated in severe COVID-19 patients and modulated by exoglycosidase digestion. Taken together, this work links the IgM N-glycosylation with COVID-19 severity and highlights the need to understand IgM glycosylation and downstream immune function during human disease.
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Details
- Title
- IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
- Creators
- IMPACC Network (Collaboration)Benjamin S Haslund-Gourley - Drexel UniversityKyra Woloszczuk - Drexel University, Microbiology and ImmunologyJintong Hou - Drexel UniversityJennifer Connors - Drexel University/Tower Health Hospital, Philadelphia, PA, USAGina Cusimano - Drexel University, Microbiology and ImmunologyMathew Bell - Drexel University, Medicine (Graduate)Bhavani Taramangalam - Drexel University/Tower Health Hospital, Philadelphia, PA, USASlim Fourati - Emory University School of MedicineNathan Mege - Drexel UniversityMariana Bernui - Drexel University, Infectious Diseases (and HIV Medicine)Matthew C Altman - Seattle UniversityFlorian Krammer - Icahn School of Medicine at Mount SinaiHarm van Bakel - Icahn School of Medicine at Mount SinaiHolden T Maecker - Stanford University School of MedicineNadine Rouphael - Emory UniversityJoann Diray-Arce - Boston Children's HospitalBrian Wigdahl - Drexel University, Microbiology and ImmunologyMichele A Kutzler - Drexel University, Infectious Diseases (and HIV Medicine)Charles B Cairns - Drexel University, College of MedicineElias K Haddad - Drexel University, Infectious Diseases (and HIV Medicine)Mary Ann Comunale - Drexel University, Microbiology and Immunology
- Publication Details
- Nature communications, Vol.15(1), 404
- Publisher
- Springer Nature
- Number of pages
- 19
- Grant note
- U19 AI077439 / NIAID NIH HHS U19 AI089992 / NIAID NIH HHS U54 AI142766 / NIAID NIH HHS U19 AI125357 / NIAID NIH HHS U19 AI057229 / NIAID NIH HHS U19 AI062629 / NIAID NIH HHS R01 AI135803 / NIAID NIH HHS U19 AI090023 / NIAID NIH HHS S10 OD030463 / NIH HHS S10 OD026880 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Medicine (Graduate); College of Medicine; Urban Health Collaborative; Infectious Diseases (and HIV Medicine); Emergency Medicine; Family (Community and Preventive) Medicine; General Internal Medicine
- Web of Science ID
- WOS:001139536800028
- Scopus ID
- 2-s2.0-85181877779
- Other Identifier
- 991021817828504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology