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Journal article
Image-Guided Biopsy for Relapsed Neuroblastoma: Focus on Safety, Adequacy for Genetic Sequencing, and Correlation of Tumor Cell Percent With Quantitative Lesion MIBG Uptake
JCO PRECISION ONCOLOGY, v 5, pp 275-285
May 2021
PMID: 34250393
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
PURPOSE Many novel therapies for relapsed and refractory neuroblastoma require tumor tissue for genomic sequencing. We analyze our experience with image-guided biopsy in these patients, focusing on safety, yield, adequacy for next-generation sequencing (NGS), and correlation of tumor cell percent (TC%) with quantitative uptake on I-123-meta-iodobenzylguanidine (MIBG) single-photon emission computed tomography with computed tomography (SPECT/CT). MATERIALS AND METHODS An 11-year retrospective review of image-guided biopsy on 66 patients (30 female), with a median age of 8.7 years (range, 0.9-49 years), who underwent 95 biopsies (55 bone and 40 soft tissue) of relapsed or refractory neuroblastoma lesions was performed. RESULTS There were seven minor complications (7%) and one major complication (1%). Neuroblastoma was detected in 88% of MIBG- or fluorodeoxyglucose-avid foci. The overall NGS adequacy was 69% (64% in bone and 74% in soft tissue,P= .37). NGS adequacy within neuroblastoma-positive biopsies was 88% (82% bone and 96% soft tissue,P= .11). NGS-adequate biopsies had a greater mean TC% than inadequates (51%v18%,P= .03). NGS-adequate biopsies had a higher mean number of needle passes (7.5v3.4,P= .0002). The mean tissue volume from NGS-adequate soft-tissue lesions was 0.16 cm(3) 0.12. Lesion:liver and lesion:psoas MIBG uptake ratios correlated with TC% (r = 0.74, r = 0.72, and n = 14). Mean TC% in NGS-adequate samples was 51%, corresponding to a lesion:liver ratio of 2.9 and a lesion:psoas ratio of 9.0. Thirty percent of biopsies showed an actionableALKmutation or other therapeutically relevant variant. CONCLUSION Image-guided biopsy for relapsed or refractory neuroblastoma was safe and likely to provide NGS data to guide therapy decisions. A lesion:liver MIBG uptake ratio of >= 3 or a lesion:psoas ratio of > 9 was associated with a TC% sufficient to deliver NGS results.
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- Title
- Image-Guided Biopsy for Relapsed Neuroblastoma: Focus on Safety, Adequacy for Genetic Sequencing, and Correlation of Tumor Cell Percent With Quantitative Lesion MIBG Uptake
- Publication Details
- JCO PRECISION ONCOLOGY, v 5, pp 275-285
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
- Number of pages
- 10
- Grant note
- Supported by NIH grants R35 CA220500 (J.M.M.) and R01 CA140198 (Y.P.M.) and grants from the Alex's Lemonade Stand Foundation (Y.P.M. and J.M.M.), the Band of Parents Foundation (Y.P.M. and J.M.M.), the Solving Kid's Cancer Foundation (Y.P.M. and J.M.M.), and the Open Hands Overflowing Hearts Foundation (Y.P.M.).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000757128800001
- Scopus ID
- 2-s2.0-85120164383
- Other Identifier
- 991021860666104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology