Journal article
Imaging genomics: data fusion in uncovering disease heritability
Trends in molecular medicine, v 29(2), pp 141-151
01 Feb 2023
PMID: 36470817
Abstract
Sequencing of the human genome in the early 2000s enabled probing of the genetic basis of disease on a scale previously unimaginable. Now, two decades later, after interrogating millions of markers in thousands of individuals, a significant portion of disease heritability still remains hidden. Recent efforts to unravel this ‘missing heritability’ have focused on garnering new insight from merging different data types, including medical imaging. Imaging offers promising intermediate phenotypes to bridge the gap between genetic variation and disease pathology. In this review we outline this fusion and provide examples of imaging genomics in a range of diseases, from oncology to cardiovascular and neurodegenerative disease. Finally, we discuss how ongoing revolutions in data science and sharing are primed to advance the field.
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Details
- Title
- Imaging genomics: data fusion in uncovering disease heritability
- Creators
- Katherine Hartmann - Hospital of the University of PennsylvaniaChristoph Y. Sadée - Stanford UniversityIshan Satwah - College of Medicine, Drexel University, Philadelphia, PA, United StatesFrancisco Carrillo-Perez - Department of Computer Architecture and Technology, University of Granada. C.I.T.I.C., Granada, SpainOlivier Gevaert - Stanford University
- Publication Details
- Trends in molecular medicine, v 29(2), pp 141-151
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- R01 CA260271 / National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) P20-00163 / Junta de Andalucía (http://data.elsevier.com/vocabulary/SciValFunders/501100011011) Gevaert Laboratory National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) R01 CA260271 / National Cancer Institute (100000054) National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) Ministerio de Ciencia, Innovación y Universidades (http://data.elsevier.com/vocabulary/SciValFunders/100014440) Fulbright Spanish Commission Junta de Andalucía (http://data.elsevier.com/vocabulary/SciValFunders/501100011011) PID2021-128317OB-I00; RTI-2018-101674-B-I00 / Ministerio de Ciencia, Innovación y Universidades (http://data.elsevier.com/vocabulary/SciValFunders/100014440)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001029535600001
- Scopus ID
- 2-s2.0-85143266427
- Other Identifier
- 991022207166004721