Journal article
Immunity to blood-stage murine malarial parasites is MHC class II dependent
Immunology letters, v 89(2)
2003
PMID: 14556985
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To determine whether MHC class II antigen presentation is essential for the induction of protective immunity against blood-stage malarial parasites, we used gene-targeted knockout (KO) mice to follow the time-course of nonlethal
Plasmodium yoelii and
Plasmodium chabaudi infections in two models of MHC class II deficiency. Infection of MHC class II KO (A
−/−) mice with either parasite species resulted in an unremitting hyperparasitemia, whereas MHC-intact control mice resolved their parasitemia. In contrast, invariant chain KO (Ii
−/−) mice, which present antigen via recycled but not nascent MHC class II molecules, eventually cured their infections when infected with
P. yoelii.
P. chabaudi parasitemia declined to subpatent levels in most Ii
−/− mice but then recrudesced. Immunity to blood-stage malaria may be achieved by cell-mediated and antibody-mediated mechanisms of immunity, as such, the findings in A
−/− mice indicate an essential role for MHC class II presentation of malarial antigens. Moreover, they suggest that protective immune responses to malarial antigens capable of eliminating blood-stage parasites are T cell dependent and can be induced with antigens processed in early and late endosomes.
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Details
- Title
- Immunity to blood-stage murine malarial parasites is MHC class II dependent
- Creators
- Francine Cigel - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USAJoan Batchelder - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USAJames M Burns - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USADeborah Yañez - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USAHenri van der Heyde - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USADean D Manning - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USAWilliam P Weidanz - Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
- Publication Details
- Immunology letters, v 89(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000186023200022
- Scopus ID
- 2-s2.0-0141527379
- Other Identifier
- 991014877803604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology