Journal article
Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions
Molecular biology reports, v 50(4), pp 3739-3753
01 Apr 2023
PMID: 36656437
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundCircadian rhythm is characterised by daily variations in biological activity to align with the light and dark cycle. These diurnal variations, in turn, influence physiological functions such as blood pressure, temperature, and sleep-wake cycle. Though it is well established that the circadian pathway is linked to pro-inflammatory responses and circulating immune cells, its association with infectious diseases is widely unknown.ObjectiveThis comprehensive review aims to describe the association between circadian rhythm and host immune response to various kinds of infection.MethodsWe conducted a literature search in databases Pubmed/Medline and Science direct. Our paper includes a comprehensive analysis of findings from articles in English which was related to our hypothesis.FindingsMolecular clocks determine circadian rhythm disruption in response to infection, influencing the host's response toward infection. Moreover, there is a complex interplay with intrinsic oscillators of pathogens and the influence of specific infectious processes on the CLOCK: BMAL1 pathway. Such mechanisms vary for bacterial and viral infections, both well studied in the literature. However, less is known about the association of parasitic infections and fungal pathogens with circadian rhythm modulation.ConclusionIt is shown that bidirectional relationships exist between circadian rhythm disruption and infectious process, which contains interplay between the host's and pathogens' circadian oscillator, immune response, and the influence of specific infectious. Further studies exploring the modulations of circadian rhythm and immunity can offer novel explanations of different susceptibilities to infection and can lead to therapeutic avenues in circadian immune modulation of infectious diseases.
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Details
- Title
- Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions
- Creators
- Helen Huang - Royal College of Surgeons in IrelandAashna Mehta - University of DebrecenJacob Kalmanovich - Drexel UniversityAyush Anand - B.P. Koirala Institute of Health SciencesMaria Chilo Bejarano - La Sierra UniversityTulika Garg - Government Medical College and HospitalNida Khan - Jinnah Sindh Medical UniversityGauvain Kankeu Tonpouwo - University of LubumbashiAnastasiia D. D. Shkodina - Poltava V.G. Korolenko National Pedagogical UniversityMainak Bardhan - National Institute of Cholera and Enteric Diseases
- Publication Details
- Molecular biology reports, v 50(4), pp 3739-3753
- Publisher
- Springer Nature
- Number of pages
- 15
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000913770900001
- Scopus ID
- 2-s2.0-85146604450
- Other Identifier
- 991021901415504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology