Journal article
Immunology of systemic sclerosis
Frontiers in bioscience, v 10(2), pp 1707-1719
01 May 2005
PMID: 15769660
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Systemic sclerosis (scleroderma; SSc) is an autoimmune disorder of unknown etiology characterized by severe and progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immunological abnormalities. Clinically, systemic sclerosis is very heterogeneous, ranging from mild limited forms of skin sclerosis (LcSSc) with minimal internal organ involvement to severe skin to multiple internal organ fibrosis and extensive skin fibrosis (DcSSc). Mortality and morbidity in systemic sclerosis is very high and are directly related to the extent of the fibrotic and microvascular alterations. The interactions between blood vessels, fibroblast activity, and immunological processes play an important role in the pathogenesis of SSc.
Metrics
Details
- Title
- Immunology of systemic sclerosis
- Creators
- Carol M Artlett - Thomas Jefferson University
- Publication Details
- Frontiers in bioscience, v 10(2), pp 1707-1719
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000232319800061
- Scopus ID
- 2-s2.0-17244364387
- Other Identifier
- 991020200888604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology