Journal article
Immunomodulation by Seminal Factors and Implications for Male-to-Female HIV-1 Transmission
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v 69(2), pp 131-137
01 Jun 2015
PMID: 25642971
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of semen in heterosexual transmission of the HIV-1 has been marginally viewed as an inert vehicle for the delivery of virus. However, studies from the field of reproductive biology have made it clear that seminal fluid is a complex and dynamic medium containing high concentrations of factors that play key roles in modulating the local immune response in the female reproductive tract during fertilization and embryogenesis. It is therefore strongly implied that the same seminal factors responsible for guiding the immune response in reproduction also play a role in male-to-female transmission of HIV-1. To begin to understand how these factors affect male-to-female HIV-1 transmission, multiple studies have comparatively profiled the contents of seminal fluid collected from uninfected and HIV-1-infected men. This review provides an overview of these studies, as well as a discussion of the potential impact of semen on HIV-1 transmission.
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Details
- Title
- Immunomodulation by Seminal Factors and Implications for Male-to-Female HIV-1 Transmission
- Creators
- Shawn Keogan - Drexel UniversityKarl Siegert - Drexel UniversityBrian Wigdahl - Drexel UniversityFred C. Krebs - Drexel Univ, Dept Microbiol & Immunol, Ctr Mol Therapeut & Resistance, Ctr Sexually Transmitted,Inst Mol Med & Infect Di, Philadelphia, PA 19102 USA
- Publication Details
- JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v 69(2), pp 131-137
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- Department of Microbiology and Immunology Institute for Molecular Medicine and Infectious Disease at the Drexel University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology
- Web of Science ID
- WOS:000369250500008
- Scopus ID
- 2-s2.0-84929943509
- Other Identifier
- 991019168767704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases