Journal article
Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis
Regenerative biomaterials, v 6(3), pp 163-174
Jun 2019
PMID: 31198584
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We previously demonstrated that octadecylamine-functionalized nanodiamond (ND-ODA) and dexamethasone (Dex)-adsorbed ND-ODA (ND-ODA–Dex) promoted anti-inflammatory and pro-regenerative behavior in human macrophages
in vitro
. In this study, we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in mice. Following local injection in limbs of mice with collagen type II-induced arthritis, microcomputed tomography showed that mice treated with a low dose of ND-ODA and ND-ODA–Dex did not experience bone loss to the levels observed in non-treated arthritic controls. A low dose of ND-ODA and ND-ODA–Dex also reduced macrophage infiltration and expression of pro-inflammatory mediators iNOS and tumor necrosis factor-α compared to the arthritic control, while a high dose of ND-ODA increased expression of these markers. Overall, these results suggest that ND-ODA may be useful as an inherently immunomodulatory platform, and support the need for an in-depth study, especially with respect to the effects of dose.
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Details
- Title
- Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis
- Creators
- Amanda Pentecost - Department of Materials Science and Engineering, College of Engineering, Drexel University, Philadelphia, PA, USAMin Ju Kim - KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South KoreaSangmin Jeon - Biomedical Research Institute, Center for Theragnosis, Korea Institute of Science and Technology, Seoul, South KoreaYoung Ji Ko - KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South KoreaIck Chan Kwon - KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, South KoreaYury Gogotsi - Department of Materials Science and Engineering, College of Engineering, Drexel University, Philadelphia, PA, USAKwangmeyung Kim - Biomedical Research Institute, Center for Theragnosis, Korea Institute of Science and Technology, Seoul, South KoreaKara L Spiller - School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA
- Publication Details
- Regenerative biomaterials, v 6(3), pp 163-174
- Publisher
- Oxford University Press
- Grant note
- ; R01 HL130037 / ; ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000482716500004
- Scopus ID
- 2-s2.0-85071148144
- Other Identifier
- 991014877837804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials