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Immunopathogenesis and immunotherapeutic approaches to type 1A diabetes
Journal article   Peer reviewed

Immunopathogenesis and immunotherapeutic approaches to type 1A diabetes

Anita Azam and George S Eisenbarth
Expert opinion on biological therapy, v 4(10), pp 1569-1575
01 Oct 2004
DOI: https://doi.org/10.1517/14712598.4.10.1569
PMID: 15461568
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

It is now clear that type 1A (immune-mediated) diabetes develops in genetically susceptible individuals where, prior to the onset of overt hyperglycaemia, there is usually a long prodrome characterised by the presence of autoimmunity directed at islet beta cells. It is the destruction of these insulin-producing cells that results in loss of metabolic regulation and the resultant hyperglycaemia and severe sequelae of type 1A diabetes. An extensive body of animal data and a developing body of human studies are now addressing therapies directed at this root immune cause of type 1A diabetes. Therapies can be considered in terms of the disease stage at which they are applied and in terms of their effects on the immune system (e.g., generalised immunosuppression, immunomodulation, antigen-specific therapies and tolerance-inducing therapies). As T cells are the primary mediators of islet beta cell destruction, it is likely that improved therapies and monitoring of T cell autoimmunity will be necessary to develop a safe and effective therapy for type 1A diabetes.

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12 citations in Web of Science
16 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Biotechnology & Applied Microbiology
Medicine, Research & Experimental
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