Journal article
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
Science immunology, v 6(62)
10 Aug 2021
PMID: 34376480
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 (NCT04378777). IMPACC collects detailed clinical, laboratory and radiographic data along with longitudinal biologic sampling of blood and respiratory secretions for in depth testing. Clinical and lab data are integrated to identify immunologic, virologic, proteomic, metabolomic and genomic features of COVID-19-related susceptibility, severity and disease progression. The goals of IMPACC are to better understand the contributions of pathogen dynamics and host immune responses to the severity and course of COVID-19 and to generate hypotheses for identification of biomarkers and effective therapeutics, including optimal timing of such interventions. In this report we summarize the IMPACC study design and protocols including clinical criteria and recruitment, multi-site standardized sample collection and processing, virologic and immunologic assays, harmonization of assay protocols, high-level analyses and the data sharing plans.
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Details
- Title
- Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
- Creators
- Nadine Rouphael - Emory UniversityHolden Maecker - Stanford UniversityRuth R. Montgomery - College Station Medical CenterJoann Diray-Arce - College Station Medical CenterSteven H. Kleinstein - College Station Medical CenterMatthew C. Altman - Benaroya Res Inst, Seattle, WA USASteven E. Bosinger - Emory UniversityWalter Eckalbar - College Station Medical CenterLeying Guan - Yale Sch Publ Hlth, New Haven, CT USACatherine L. Hough - University of PortlandFlorian Krammer - College Station Medical CenterCharles Langelier - College Station Medical CenterOfer Levy - College Station Medical CenterKerry McEnaney - College Station Medical CenterBjoern Peters - La Jolla Inst Immunol, La Jolla, CA USAAdeeb Rahman - College Station Medical CenterJayant Rajan - College Station Medical CenterSteven Sigelman - NIAID, NIH, Rockville, MD 20852 USAHanno Steen - College Station Medical CenterHarm van Bakel - College Station Medical CenterAlyssa Ward - College Station Medical CenterMichael R. Wilson - College Station Medical CenterPrescott Woodruff - College Station Medical CenterColin R. Zamecnik - College Station Medical CenterAlison D. Augustine - NIAID, NIH, Rockville, MD 20852 USAAl Ozonoff - College Station Medical CenterElaine F. Reed - University of California, Los AngelesPatrice M. Becker - NIAID, NIH, Rockville, MD 20852 USANelson Agudelo Higuita - University of OklahomaMark A. Atkinson - Univ Florida, Gainesville, FL 32611 USALindsey R. Baden - Brigham and Women's HospitalChristian Bime - University of ArizonaScott C. Brakenridge - Univ Florida, Gainesville, FL 32611 USACarolyn S. Calfee - College Station Medical CenterCharles B. Cairns - Drexel University, College of MedicineDavid Corry - College Station Medical CenterMark M. Davis - Stanford UniversityLauren I. R. Ehrlich - Univ Texas Austin, Austin, TX 78712 USAElias K. Haddad - Drexel University, College of MedicineDavid J. Erle - College Station Medical CenterAna Fernandez-Sesma - College Station Medical CenterDavid A. Hafler - College Station Medical CenterFarrah Kheradmand - College Station Medical CenterMonica Kraft - University of ArizonaGrace A. McComsey - College Station Medical CenterEsther Melamed - Univ Texas Austin, Austin, TX 78712 USAWilliam Messer - University of PortlandJordan Metcalf - University of OklahomaKari C. Nadeau - Stanford UniversityBali Pulendran - Emory UniversityNadine Rouphaell - Emory UniversityMinnie Sarwal - College Station Medical CenterJoanna Schaenman - Univ Calif Los Angeles, Los Angeles, CA 90024 USARafick Sekaly - Emory UniversityAlbert C. Shaw - College Station Medical CenterViviana Simon - College Station Medical CenterIMPACC Network Steering Comm
- Publication Details
- Science immunology, v 6(62)
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 17
- Grant note
- R01AI104870; R01AI132774; R01AI135803; R01AI145835; U19AI057229; U19AI062629; U19AI077439; U19AI089992; U19AI090023; U19AI118608; U19AI118610; U19AI125357; U19AI128910; U19AI128913; U54AI142766; U24AI52179 / National Institute of Allergy and Infectious Diseases (NIAID), a part of the U.S. National Institutes of Health (NIH) P51 OD011132; S10 OD026799 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Department of Pediatrics
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000684294900003
- Scopus ID
- 2-s2.0-85113872887
- Other Identifier
- 991020099666504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology