Journal article
Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study
JOURNAL OF ALZHEIMERS DISEASE, v 96(1), p329
2023
PMID: 37742646
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: A carbohydrate-restricted diet aimed at lowering insulin levels has the potential to slow Alzheimer's disease (AD). Restricting carbohydrate consumption reduces insulin resistance, which could improve glucose uptake and neural health. A hallmark feature of AD is widespread cortical thinning; however, no study has demonstrated that lower net carbohydrate (nCHO) intake is linked to attenuated cortical atrophy in patients with AD and confirmed amyloidosis. Objective: We tested the hypothesis that individuals with AD and confirmed amyloid burden eating a carbohydrate-restricted diet have thicker cortex than those eating a moderate-to-high carbohydrate diet. Methods: A total of 31 patients (mean age 71.4 +/- 7.0 years) with AD and confirmed amyloid burden were divided into two groups based on a 130 g/day nCHO cutoff. Cortical thickness was estimated from T1-weighted MRI using FreeSurfer. Cortical surface analyses were corrected for multiple comparisons using cluster-wise probability. We assessed group differences using a two-tailed two-independent sample t-test. Linear regression analyses using nCHO as a continuous variable, accounting for confounders, were also conducted. Results: The lower nCHO group had significantly thicker cortex within somatomotor and visual networks. Linear regression analysis revealed that lower nCHO intake levels had a significant association with cortical thickness within the frontoparietal, cingulo-opercular, and visual networks. Conclusions: Restricting carbohydrates may be associated with reduced atrophy in patients with AD. Lowering nCHO to under 130 g/day would allow patients to follow the well-validated MIND diet while benefiting from lower insulin levels.
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- Title
- Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study
- Publication Details
- JOURNAL OF ALZHEIMERS DISEASE, v 96(1), p329
- Publisher
- IOS PRESS; AMSTERDAM
- Grant note
- This work is supported by the Pacific Neuroscience Institute Foundation, including the generous support of the Barbara and John McLoughlin Family as well as the Cary and Will Singleton Family; Providence St. `Joseph Health, Seattle, WA[Alzheimer'sTranslational Pillar (ATP)]; Saint John's Health Center Foundation; and the National Institutes of Health [U01AG046139, RF1AG057443, U01AG061359, R01AG062514, R21AG061494].The EPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC-UU 12015/1) and Cancer Research UK (C864/A14136).; Support for the research behind FreeSurfer was provided in part by the National Center for Research Resources (P41-RR14075, R01 RR16594-01A1 and the NCRR BIRN Morphometric Project BIRN002, U24 RR021382), the National Institute for Neurological Disorders and Stroke (R01 NS052585-01)), the National Institute of Biomedical Imaging and Bioengineering, as well as the Mental Illness and Neuroscience Discovery (MIND) Institute, and is part of the National Alliance for Medical Image Computing (NAMIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research, Grant U54 EB005149. Support for providing engineering advice and support for testing and open-sourcing of FreeSurfer was provided in part by the NA-MIC (NIH Roadmap for Medical Research Grant U54 EB005149).
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:001092311300028
- Scopus ID
- 2-s2.0-85175497986
- Other Identifier
- 991021860727704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences