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Impact of Physician-Defined Flares on Quality of Life and Work Impairment: An International Survey of 2238 Patients With Psoriatic Arthritis
Journal article   Open access   Peer reviewed

Impact of Physician-Defined Flares on Quality of Life and Work Impairment: An International Survey of 2238 Patients With Psoriatic Arthritis

Ana-Maria Orbai, William Tillett, Suzanne Grieb, Steve Peterson, Elizabeth A Holdsworth, Nicola Booth, Soumya D Chakravarty and Laure Gossec
Journal of rheumatology, v 50(1), pp 76-83
Jan 2023
DOI: https://doi.org/10.3899/jrheum.211302
PMID: 35970528
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3899/jrheum.211302View
Published, Version of Record (VoR) Open

Abstract

Arthritis, Psoriatic Cross-Sectional Studies Humans Physicians Severity of Illness Index Surveys and Questionnaires Quality of Life United States
To describe psoriatic arthritis (PsA) flares and their effect on patient-reported outcomes (PROs). Cross-sectional surveys of rheumatologists/dermatologists and their patients with PsA were conducted in France, Germany, Italy, Spain, the United Kingdom, and the United States, capturing data on physician-reported patient flare status, demographics, PsA severity, and clinical outcomes. Patient-completed surveys captured data on PROs: 5-level EuroQol 5-dimension, Work Productivity and Activity Impairment questionnaire, Health Assessment Questionnaire-Disability Index, and 12-item Psoriatic Arthritis Impact of Disease questionnaire. Patients were compared by flare status using parametric and nonparametric tests. Multivariate regression was used to identify flare associations. Multivariate logistic regression adjusted for patient demographics and physician specialty assessed the effect of flare status. Among 2238 patients (586 from the US, 1652 from Europe) managed by 572 physicians, physician-reported flare was present for 168 patients (7.5%), and self-reported flare was present for 95 patients (10% of available data). Mean (SD) flare count over 12 months was 2.2 (4.9), lasting on average 16.4 (16.2) days. Flare status was linked to worse PROs. Patients who had not flared in the last 12 months or had never flared had a higher quality of life, lower overall work impairment, and a lower degree of disability compared with patients who were currently experiencing a flare (all; < 0.01). Actively experiencing a flare adversely affected QOL, disability, and work productivity. PsA flares should be routinely assessed and managed in clinical care.

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Industry collaboration
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International collaboration
Web of Science research areas
Rheumatology
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