Journal article
Impact of Tat Genetic Variation on HIV-1 Disease
Advances in virology, v 2012, 123605
2012
PMID: 22899925
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in transcriptional activation of HIV-1 gene expression. Functional domains of Tat and its interaction with transactivation response element RNA and cellular transcription factors have been examined. Genetic variation within
tat
of different HIV-1 subtypes has been shown to affect the interaction of the viral transactivator with cellular and/or viral proteins, influencing the overall level of transcriptional activation as well as its action as a neurotoxic protein. Consequently, the genetic variability within
tat
may impact the molecular architecture of functional domains of the Tat protein that may impact HIV pathogenesis and disease. Tat as a therapeutic target for anti-HIV drugs has also been discussed.
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Details
- Title
- Impact of Tat Genetic Variation on HIV-1 Disease
- Creators
- Luna Li - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USASatinder Dahiya - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USASandhya Kortagere - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USABenjamas Aiamkitsumrit - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USADavid Cunningham - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USAVanessa Pirrone - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USAMichael R Nonnemacher - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USABrian Wigdahl - Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, MS no. 1013A, Philadelphia, PA 19102, USA
- Publication Details
- Advances in virology, v 2012, 123605
- Publisher
- Hindawi Publishing Corporation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000214662800001
- Scopus ID
- 2-s2.0-84873863865
- Other Identifier
- 991014878541904721
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- Web of Science research areas
- Virology