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Journal article
Impact of activity-based recovery training and desmopressin on spinal cord injury-induced polyuria in Wistar rats
The journal of spinal cord medicine, v ahead-of-print(ahead-of-print)
02 Nov 2023
PMID: 35604340
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Activity-based recovery training (ABRT) reverses spinal cord injury (SCI) induced polyuria and alterations of biomarkers involved with fluid balance, including expression levels of kidney vasopressin 2 receptors. However, void volumes do not return to pre-injury baseline levels, indicating a combinatorial approach may be necessary.
In the current study, acute effects of a pharmacological intervention versus placebo were examined in male rats that had received 70 daily ABRT sessions. The treatment, desmopressin (DDAVP - synthetic analogue of arginine vasopressin), an antidiuretic therapy used for the management of bedwetting in children and central diabetes insipidus, has previously shown some promise in a few limited cohorts of SCI individuals having nocturnal polyuria.
A total of 70 sessions of ABRT over a 10-week timeframe again reduced the overproduction of urine, but not completely to pre-SCI baseline levels. DDAVP treatment maintained but did not further reduce the level of urine output in the ABRT group without continuous exercise, demonstrating either intervention/treatment alone is effective, despite no additive effect. Although intake did not change from pre-injury levels despite polyuria, DDAVP treatment also reduced drink volume.
Further studies are needed as the mechanisms underlying changes in fluid and solute balance are likely multi-factorial involving a complex interaction between the neural (both central and peripheral) control of systems mediating thirst, urinary output, and cardiovascular regulation.
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Details
- Title
- Impact of activity-based recovery training and desmopressin on spinal cord injury-induced polyuria in Wistar rats
- Creators
- Charles H. Hubscher - University of LouisvilleJason H. Gumbel - University of LouisvilleJames E. Armstrong - University of LouisvilleLynnette R. Montgomery
- Publication Details
- The journal of spinal cord medicine, v ahead-of-print(ahead-of-print)
- Publisher
- Taylor & Francis
- Grant note
- 546893 / Craig H Neilsen Foundation (10.13039/100005191) W81XWH-15-1-0656 / Department of Defense (10.13039/100000005)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:000799134900001
- Scopus ID
- 2-s2.0-85130875807
- Other Identifier
- 991021866418404721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology