Journal article
Impact of age on markers of HIV-1 disease
Future virology, v 8(1), pp 81-101
Jan 2013
PMID: 23596462
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging is a complicated process characterized by a progressive loss of homeostasis, which results in an increased vulnerability to multiple diseases. HIV-1-infected patients demonstrate a premature aging phenotype and develop certain age-related diseases earlier in their lifespan than what is seen in the general population. Age-related comorbidities may include the development of bone disease, metabolic disorders, neurologic impairment and immunosenescence. Age also appears to have an effect on traditional markers of HIV-1 disease progression, including CD4
+
T-cell count and viral load. These effects are not only a consequence of HIV-1 infection, but in many cases, are also linked to antiretroviral therapy. This review summarizes the complex interplay between HIV-1 infection and aging, and the impact that aging has on markers of HIV-1 disease.
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Details
- Title
- Impact of age on markers of HIV-1 disease
- Creators
- Vanessa Pirrone - Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USADavid J Libon - Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19129, USAChristian Sell - Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19129, USAChad A Lerner - Department of Pathology, Drexel University College of Medicine, Philadelphia, PA 19129, USAMichael R Nonnemacher - Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USABrian Wigdahl - Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USA
- Publication Details
- Future virology, v 8(1), pp 81-101
- Grant note
- R01 DA019807 || DA / National Institute on Drug Abuse : NIDA R01 NS032092 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Microbiology and Immunology
- Web of Science ID
- WOS:000314576900011
- Scopus ID
- 2-s2.0-84871540805
- Other Identifier
- 991014878069104721
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- Web of Science research areas
- Virology