Journal article
Impact of cytomegalovirus infection on gene expression profile in heart transplant recipients
The Journal of heart and lung transplantation, v 40(2), pp 101-107
Feb 2021
PMID: 33341360
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection in heart transplant (HT) recipients. The effect of a CMV infection on the gene expression profiling (GEP, AlloMap) scores in the absence of acute rejection is not known.
Data from 14,985 samples collected from 2,288 adult HT recipients enrolled in Outcomes AlloMap Registry were analyzed. Patients with known CMV serology at the time of HT who had at least 1 AlloMap score reported during follow-up were included. AlloMap scores for those patients with CMV (but no ongoing rejection) were compared with those who were never infected. An exploratory analysis on the impact of CMV on available donor-derived cell-free DNA (AlloSure) was also performed.
A total of 218 patients (10%) were reported to have CMV infection after transplantation. AlloMap score in those samples with CMV infection (n = 311) had a GEP score (34; range: 29–36) significantly higher than the GEP score from samples (n = 14,674) obtained in the absence of CMV infection (30; range: 26–34; p < 0.0001). Both asymptomatic viremia and CMV disease demonstrated significantly higher AlloMap scores than no CMV infection samples (median scores: 33, 35, and 30, respectively; p < 0.0001). AlloSure levels, available for 776 samples, were not significantly different (median: 0.23% in 18 samples with CMV infection vs 0.15% in 776 samples without CMV infection; p = 0.66).
CMV infection in HT recipients is associated with an increase in AlloMap score, whereas AlloSure results do not appear to be impacted. This information should be considered when clinically interpreting abnormal/high AlloMap scores in HT recipients.
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Details
- Title
- Impact of cytomegalovirus infection on gene expression profile in heart transplant recipients
- Creators
- Manreet K. Kanwar - Allegheny Health NetworkKiran K. Khush - Stanford UniversitySean Pinney - Icahn School of Medicine at Mount SinaiClaire Sherman - PAX ScientificShelley Hall - Baylor University Medical CenterJeffrey Teuteberg - Stanford UniversityNir Uriel - New York Hospital QueensJon Kobashigawa - Cedars-Sinai Smidt Heart Institute
- Publication Details
- The Journal of heart and lung transplantation, v 40(2), pp 101-107
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiology
- Web of Science ID
- WOS:000609897600004
- Scopus ID
- 2-s2.0-85097768172
- Other Identifier
- 991021932099404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery
- Transplantation