Journal article
Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort
Annals of the rheumatic diseases, v 74(8), pp 1530-1536
01 Aug 2015
PMID: 24692585
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundThe metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE.MethodsRecently diagnosed (<15 months) patients with SLE from 30 centres across 11 countries were enrolled into the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort from 2000 onwards. Baseline and annual assessments recorded clinical, laboratory and therapeutic data. A longitudinal analysis of factors associated with MetS in the first 2 years of follow-up was performed using random effects logistic regression.ResultsWe studied 1150 patients with a mean (SD) age of 34.9 (13.6) years and disease duration at enrolment of 24.2 (18.0) weeks. In those with complete data, MetS prevalence was 38.2% at enrolment, 34.8% at year 1 and 35.4% at year 2. In a multivariable random effects model that included data from all visits, prior MetS status, baseline renal disease, SLICC Damage Index >1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2 years of follow-up in the cohort.ConclusionsMetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course.
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Details
- Title
- Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort
- Creators
- Ben Parker - University of ManchesterMurray B Urowitz - Toronto Western HospitalDafna D Gladman - Toronto Western HospitalMark Lunt - University of ManchesterRachelle Donn - University of ManchesterSang-Cheol Bae - Hanyang University Seoul HospitalJorge Sanchez-Guerrero - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránJuanita Romero-Diaz - Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránCaroline Gordon - University of BirminghamDaniel J Wallace - Cedars-Sinai Medical CenterAnn E Clarke - McGill University Health CentreSasha Bernatsky - McGill University Health CentreEllen M Ginzler - SUNY Downstate Health Sciences UniversityDavid A Isenberg - University College LondonAnisur Rahman - University College LondonJoan T Merrill - Oklahoma Medical Research FoundationGraciela S Alarcón - University of Alabama at BirminghamBarri J Fessler - University of Alabama at BirminghamPaul R Fortin - Université LavalJohn G Hanly - Queen Elizabeth II Health Sciences CentreMichelle Petri - Johns Hopkins MedicineKristjan Steinsson - Reykjavík UniversityMary Anne Dooley - University of North Carolina at Chapel HillSusan Manzi - Allegheny Health NetworkMunther A Khamashta - St Thomas' HospitalRosalind Ramsey-Goldman - Northwestern UniversityAsad A Zoma - Hairmyres HospitalGunnar K Sturfelt - Lund UniversityOla Nived - Lund UniversityCynthia Aranow - Feinstein Institute for Medical ResearchMeggan Mackay - Feinstein Institute for Medical ResearchManuel Ramos-Casals - Consorci Institut D'Investigacions Biomediques August Pi I SunyerRonald F van Vollenhoven - Karolinska InstitutetKenneth C Kalunian - University of California San DiegoGuillermo Ruiz-Irastorza - University of the Basque CountryS Sam Lim - Emory UniversityDiane L Kamen - Medical University of South CarolinaChristine A Peschken - University of ManitobaMurat Inanc - Istanbul UniversityIan N Bruce - Manchester Academic Health Science Centre
- Publication Details
- Annals of the rheumatic diseases, v 74(8), pp 1530-1536
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000357683600020
- Scopus ID
- 2-s2.0-84940393297
- Other Identifier
- 991021934007304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology