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Journal article
Impact of histological grade on oncologic outcomes in clinical stage I patients with endometrial carcinoma patients after definitive primary radiation therapy
International journal of gynecological cancer, v 29(5), pp 890-896
Jun 2019
PMID: 31079061
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives To determine the impact of histological grade on overall survival in patients with clinical stage I endometrioid endometrial adenocarcinoma when radiation therapy is used as primary definitive treatment.
Methods Patients with stage I endometrioid endometrial adenocarcinomas who underwent definitive radiation therapy with brachytherapy +/- external beam radiation therapy were identified from the National Cancer Database. Overall survival was estimated using the Kaplan-Meier method. Univariable and multivariable analyses were performed to determine factors affecting overall survival. Inverse probability of treatment weights were also used in multivariable analysis to estimate casual effects of external beam radiation therapy.
Results A total of 947 patients were identified. Median overall survival for grade 1, grade 2, and grade 3 tumors was 62 months (95% CI 53.8 to 70.2), 48.5 months (95% CI 38.2 to 58.8), and 33.5 months (95% CI: 23.1 to 43.8), respectively. Grade, age, and insurance status were associated with overall survival in univariate analysis with only grade and age remaining significant in multivariate analysis. Brachytherapy with external beam radiation therapy was not associated with survival in comparison with brachytherapy alone. Compared with grade 1 tumors, patients with grade 3 (HR 1.4, 95% CI 1.15 to 1.89), but not grade 2 (HR 1.0, 95% CI 0.82 to 1.26), had an increased risk of death, which persisted in an inverse probability of treatment weights-adjusted model (HR 1.56, 95% CI 1.21 to 1.93).
Conclusions Patients with grade 3 stage I endometrioid endometrial adenocarcinoma treated with primary definitive radiation therapy have worse survival than those with lower grade tumors. Addition of external beam radiation therapy to brachytherapy did not affect survival.
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Details
- Title
- Impact of histological grade on oncologic outcomes in clinical stage I patients with endometrial carcinoma patients after definitive primary radiation therapy
- Creators
- Adria Suarez Mora - Magee-Womens HospitalZachary Horne - UPMC Hillman Cancer CenterSarah Taylor - Magee-Womens HospitalAlexander Babatunde Olawaiye - Magee-Womens HospitalSushil Beriwal - University of Pittsburgh Medical CenterMichelle Boisen - Magee-Womens HospitalJessica Berger - Magee-Womens HospitalPaniti Sukumvanich - Magee-Womens Hospital
- Publication Details
- International journal of gynecological cancer, v 29(5), pp 890-896
- Publisher
- Bmj Publishing Group
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000471154800010
- Scopus ID
- 2-s2.0-85067808748
- Other Identifier
- 991021897258104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Obstetrics & Gynecology
- Oncology