Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan

Longjian Liu; Katsuyuki Miura; Akira Fujiyoshi; Aya Kadota; Naoko Miyagawa; Yasuyuki Nakamura; Takayoshi Ohkubo; Akira Okayama; Tomonori Okamura; Hirotsugu Ueshima

doi:10.1016/j.amjcard.2013.08.042

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Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan

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Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan

Longjian Liu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Yasuyuki Nakamura, Takayoshi Ohkubo, Akira Okayama, Tomonori Okamura and Hirotsugu Ueshima

The American journal of cardiology, v 113(1), pp 84-89

01 Jan 2014

DOI: https://doi.org/10.1016/j.amjcard.2013.08.042

PMID: 24169008

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Abstract

Japan - epidemiology

United States - epidemiology

Prevalence

Survival Rate - trends

Humans

Middle Aged

Risk Factors

Male

Metabolic Syndrome - complications

Cardiovascular Diseases - complications

Cardiovascular Diseases - mortality

Adult

Female

Retrospective Studies

Population Surveillance

Metabolic Syndrome - epidemiology

The United States has a higher prevalence of metabolic syndrome (MS) and cardiovascular disease (CVD) mortality than Japan, but it is unknown how much of the difference in MS accounts for the mortality difference. The aim of this study was to examine the impact of MS on the excess CVD mortality in the United States compared with that in Japan. Data from the United States Third National Health and Nutrition Examination Survey (NHANES III; n = 12,561) and the Japanese National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in Aged (NIPPON DATA; n = 7,453) were analyzed. MS was defined as ≥3 of 5 risk factors (obesity, high blood pressure, decreased high-density lipoprotein cholesterol, elevated glycosylated hemoglobin, and elevated triglycerides). The results show that after a median of 13.8 years of follow-up in the United States, 1,683 patients died from CVD (11.75 per 1,000 person-years), and after a median of 15 years of follow-up in Japan, 369 patients died from CVD (3.56 per 1,000 person-years). The age-adjusted prevalence of MS was 26.7% in the United States and 19.3% in Japan. Of 5 MS factors, obesity, high blood pressure, elevated triglycerides, and glycosylated hemoglobin in the United States, and high blood pressure and elevated glycosylated hemoglobin in Japan were significant risk factors for CVD mortality. Estimates of 13.3% and 44% of the excess CVD mortality for the United States could be explained by the higher prevalence of MS and MS plus baseline CVD history than in Japan. In conclusion, the present study is the first to quantitatively demonstrate that MS and MS plus baseline CVD history may significantly contribute to the explanation of excess CVD mortality in the United States compared with Japan.

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Title: Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan
Creators: Longjian Liu - Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, Pennsylvania. Electronic address: longjian.liu@drexel.edu
Katsuyuki Miura - Department of Health Science, Shiga University of Medical Science, Otsu, Japan
Akira Fujiyoshi - Department of Health Science, Shiga University of Medical Science, Otsu, Japan
Aya Kadota - Department of Health Science, Shiga University of Medical Science, Otsu, Japan; Department of School Nursing and Health Education, Osaka Kyoiku University, Kashiwara, Japan
Naoko Miyagawa - Department of Health Science, Shiga University of Medical Science, Otsu, Japan
Yasuyuki Nakamura - Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan
Takayoshi Ohkubo - Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan
Akira Okayama - The First Institute for Health Promotion and Health Care, Japanese Anti-Tuberculosis Association, Tokyo, Japan
Tomonori Okamura - Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan
Hirotsugu Ueshima - Department of Health Science, Shiga University of Medical Science, Otsu, Japan; Lifestyle-Related Disease Prevention Center, Shiga University of Medical Science, Otsu, Japan
Publication Details: The American journal of cardiology, v 113(1), pp 84-89
Publisher: Elsevier; United States
Resource Type: Journal article
Language: English
Academic Unit: Epidemiology and Biostatistics
Web of Science ID: WOS:000329333800015
Scopus ID: 2-s2.0-84890428803
Other Identifier: 991014877699704721

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Collaboration types: Domestic collaboration; International collaboration
Web of Science research areas: Cardiac & Cardiovascular Systems

Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan

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Abstract

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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