Journal article
Impact of multiple comparisons in randomized clinical trials
The American journal of medicine, v 83(3), pp 545-550
1987
PMID: 3661589
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The randomized clinical trial is the preferred research design for evaluating competing diagnostic and therapeutic alternatives, but confidence in the conclusions from a randomized clinical trial depends on the authors' attention to acknowledged methodologic and statistical standards. This survey assessed the level of attention to the problem of multiple comparisons in the analyses of contemporary randomized clinical trials. Of the 67 trials surveyed, 66 (99 percent) performed multiple comparisons with a mean of 30 therapeutic comparisons per trial. When criteria for statistical impairment were applied, 50 trials (75 percent) had the statistical significance of at least one comparison impaired by the problem of multiple comparisons, and 15 (22 percent) had the statistical significance of all comparisons impaired by the problem of multiple comparisons. Although some statistical techniques are available, there still exists a great need for future work to clarify further the problem of multiple comparisons and determine how the impact of this problem can best be minimized in subsequent research.
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Details
- Title
- Impact of multiple comparisons in randomized clinical trials
- Creators
- David Gary Smith - Departments of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USAJohn ClemensWilliam CredeMary HarveyEdward J Gracely - Departments of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
- Publication Details
- The American journal of medicine, v 83(3), pp 545-550
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:A1987K154300022
- Scopus ID
- 2-s2.0-0023613630
- Other Identifier
- 991014878402704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, General & Internal