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Impact of powder-binder interactions on 3D printability of pharmaceutical tablets using drop test methodology
Journal article   Peer reviewed

Impact of powder-binder interactions on 3D printability of pharmaceutical tablets using drop test methodology

Koyel Sen, Raj Mukherjee, Sameera Sansare, Aritra Halder, Hooman Kashi, Anson W.K. Ma and Bodhisattwa Chaudhuri
European journal of pharmaceutical sciences, v 160, 105755
01 May 2021
DOI: https://doi.org/10.1016/j.ejps.2021.105755
PMID: 33588046
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

3D printing process Binder jet Drop test Formulation development Ink jet 3D printing Pharmaceutical sciences
In this study, a pre-screening test has been developed for the binder-jet 3D printing process (BJ3DP) which has been validated using statistical analysis. The pre-screening test or drop test has been adapted from the wet granulation field and modified later on to be used for tablet manufacturing in BJ3DP. Initially, a total of eight powders and ten water-based binder solutions have been introduced in the preliminary test to understand the powder-binder interactions. Afterward, based on the preliminary test results, three blends were developed which had undergone the same drop test. All these powder and binder combinations were then used for 3D printing. The key parameters such as mechanical strength and shape factors of the drop test agglomerates and 3D printed tablets were then compared using multiple linear regressions. Few dimensionless parameters were introduced in this study such as binding capacity and binding index to capture the printability properties of the powders used in this study. Significant relations (p<0.05) were found between the drop test and the BJ3DP process. Application of drop test was carried out to establish a prescreening test, ii) to develop new blend formulations as well as iii) to develop a fundamental understanding of powder-binder interaction during BJ3DP process Schematic representation of application of drop test as a pre-screening test for binder jet 3D printing process [Display omitted]

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21 citations in Web of Science
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Web of Science research areas
Pharmacology & Pharmacy
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