Journal article
Impact of the COVID-19 pandemic on hospitalizations with hepatocellular carcinoma in the United States
Expert review of gastroenterology & hepatology, v 18(1-3), pp 113-119
2024
PMID: 38353612
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundWe studied the temporal trends of hepatocellular carcinoma (HCC)-related hospitalizations and potential predictors of in-hospital mortality around the COVID-19 pandemic.Research design and methodsUsing the International Classification of Diseases code, we used the National Inpatient Sample 2019-2020 and defined HCC and its underlying etiology. To assess the impact of the COVID-19 pandemic on hospitalization and in-hospital mortality, the study period was divided into the pre-COVID-19 era (2019 Q1-2020 Q1) and the COVID-19 era (2020 Q2-2020 Q4). Quarterly trends in etiology-based hospitalizations with HCC and predictors of in-hospital mortality among hospitalizations with HCC were determined.ResultsHospitalization rates for HCC, as well as viral hepatitis-related HCC hospitalization rates, remained stable, while hospitalizations with alcohol-related liver disease (ALD, quarterly percentage change [QPC]: 2.1%; 95% confidence interval [CI]: 0.1%-4.2%) increased steadily. Hospitalization related to nonalcoholic fatty liver disease (NAFLD)-related HCC increased significantly steeper in the COVID-19 era (QPC: 6.6%; 95% CI: 4.0%-9.3%) than in the pre-COVID-19 era (QPC: 0.7%; 95% CI: 0.2%-1.3%). COVID-19 infection was independently associated with in-hospital mortality among hospitalizations with HCC (odds ratio: 1.94, 95% CI: 1.30-2.88).ConclusionHospitalization rates for viral hepatitis-related HCC remained stable, while those for HCC due to ALD and NAFLD increased during the COVID-19 pandemic.
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Details
- Title
- Impact of the COVID-19 pandemic on hospitalizations with hepatocellular carcinoma in the United States
- Creators
- Peter Konyn - Stanford UniversityBrandon J. Perumpail - St. Christopher's Hospital for ChildrenKarn Wijarnpreecha - University of ArizonaGeorge Cholankeril - Baylor College of MedicineAijaz Ahmed - Stanford UniversityDonghee Kim (Corresponding Author) - Stanford University
- Publication Details
- Expert review of gastroenterology & hepatology, v 18(1-3), pp 113-119
- Publisher
- Taylor & Francis
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001165867400001
- Scopus ID
- 2-s2.0-85186225232
- Other Identifier
- 991022202116104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology