Journal article
Impacts of Antimalarial Drugs on Plasmodium falciparum Drug Resistance Markers, Western Kenya, 2003-2015
The American journal of tropical medicine and hygiene, v 98(3), pp 692-699
01 Jan 2018
PMID: 29363453
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Antimalarial drug resistance has threatened global malaria control since chloroquine (CQ)-resistant Plasmodium falciparum emerged in Asia in the 1950s. Understanding the impacts of changing antimalarial drug policy on resistance is critical for resistance management. Plasmodium falciparum isolates were collected from 2003 to 2015 in western Kenya and analyzed for genetic markers associated with resistance to CQ (Pfcrt), sulfadoxine-pyrimethamine (SP) (Pfdhfr/Pfdhps), and artemether-lumefantrine (AL) (PfKelch13/Pfmdr1) antimalarials. In addition, household antimalarial drug use surveys were administered. Pfcrt 76T prevalence decreased from 76% to 6% from 2003 to 2015. Pfdhfr/Pfdhps quintuple mutants decreased from 70% in 2003 to 14% in 2008, but increased to near fixation by 2015. SP "super resistant" alleles Pfdhps 581G and 613S/T were not detected in the 2015 samples that were assessed. The Pfmdr1 N86-184F-D1246 haplotype associated with decreased lumefantrine susceptibility increased significantly from 4% in 2005 to 51% in 2015. No PfKelch13 mutations that have been previously associated with artemisinin resistance were detected in the study populations. The increase in Pfdhfr/Pfdhps quintuple mutants that associates with SP resistance may have resulted from the increased usage of SP for intermittent preventative therapy in pregnancy (IPTp) and for malaria treatment in the community. Prevalent Pfdhfr/Pfdhps mutations call for careful monitoring of SP resistance and effectiveness of the current IPTp program in Kenya. In addition, the commonly occurring Pfmdr1 N86-184F-D1246 haplotype associated with increased lumefantrine tolerance calls for surveillance of AL efficacy in Kenya, as well as consideration for a rotating artemisinin-combination therapy regimen.
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Details
- Title
- Impacts of Antimalarial Drugs on Plasmodium falciparum Drug Resistance Markers, Western Kenya, 2003-2015
- Creators
- Elizabeth Hemming-Schroeder - University of California, IrvineEmuejevuoke Umukoro - University of California, IrvineEugenia Lo - University of North Carolina at CharlotteBecky Fung - University of California, IrvinePedro Tomas-Domingo - University of California, IrvineGuofa Zhou - University of California, IrvineDaibin Zhong - University of California, IrvineAmruta Dixit - University of California, IrvineHarrysone Atieli - Kenya Medical Research InstituteAndrew Githeko - Kenya Medical Research InstituteAnne Vardo-Zalik - Pennsylvania State UniversityGuiyun Yan - University of California, Irvine
- Publication Details
- The American journal of tropical medicine and hygiene, v 98(3), pp 692-699
- Publisher
- Amer Soc Trop Med & Hygiene
- Number of pages
- 8
- Grant note
- D43TW001505 / FOGARTY INTERNATIONAL CENTER; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC) R01 A1050243; D43 TW01505; U19 AI129326 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AI050243 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000430952800011
- Scopus ID
- 2-s2.0-85043527373
- Other Identifier
- 991022192518304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Tropical Medicine