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Journal article
Impacts of center and clinical factors in antihypertensive medication use after kidney transplantation
CLINICAL TRANSPLANTATION, v 34(3), e13803
Mar 2020
PMID: 31997429
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hypertension guidelines recommend calcium channel blockers (CCBs), thiazide diuretics, and angiotensin-converting-enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs) as first-line agents to treat hypertension. Hypertension is common among kidney transplant (KTx) recipients, but data are limited regarding patterns of antihypertensive medication (AHM) use in this population. We examined a novel database that links national registry data for adult KTx recipients (age > 18 years) with AHM fill records from a pharmaceutical claims warehouse (2007-2016) to describe use and correlates of AHM use during months 7-12 post-transplant. For patients filling AHMs, individual agents used included: dihydropyridine (DHP) CCBs, 55.6%; beta-blockers (BBs), 52.8%; diuretics, 30.0%; ACEi/ARBs, 21.1%; non-DHP CCBs, 3.0%; and others, 20.1%. Both BB and ACEi/ARB use were significantly lower in the time period following the 2014 Eighth Joint National Committee (JNC-8) guidelines (2014-2016), compared with an earlier period (2007-2013). The median odds ratios generated from case-factor adjusted models supported variation in use of ACEi/ARBs (1.51) and BBs (1.55) across transplant centers. Contrary to hypertension guidelines for the general population, KTx recipients are prescribed relatively more BBs and fewer ACEi/ARBs. The clinical impact of this AHM prescribing pattern warrants further study.
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Details
- Title
- Impacts of center and clinical factors in antihypertensive medication use after kidney transplantation
- Publication Details
- CLINICAL TRANSPLANTATION, v 34(3), e13803
- Publisher
- WILEY; HOBOKEN
- Grant note
- National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: R01DK102981
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000516980200001
- Scopus ID
- 2-s2.0-85080115432
- Other Identifier
- 991021860767904721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Surgery
- Transplantation