Journal article
Impacts of maturation on the micromechanics of the meniscus extracellular matrix
Journal of biomechanics, v 72
27 Apr 2018
PMID: 29555076
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To elucidate how maturation impacts the structure and mechanics of meniscus extracellular matrix (ECM) at the length scale of collagen fibrils and fibers, we tested the micromechanical properties of fetal and adult bovine menisci via atomic force microscopy (AFM)-nanoindentation. For circumferential fibers, we detected significant increase in the effective indentation modulus, Eind, with age. Such impact is in agreement with the increase in collagen fibril diameter and alignment during maturation, and is more pronounced in the outer zone, where collagen fibrils are more aligned and packed. Meanwhile, maturation also markedly increases the Eind of radial tie fibers, but not those of intact surface or superficial layer. These results provide new insights into the effect of maturation on the assembly of meniscus ECM, and enable the design of new meniscus repair strategies by modulating local ECM structure and mechanical behaviors.
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Details
- Title
- Impacts of maturation on the micromechanics of the meniscus extracellular matrix
- Creators
- Qing Li - Drexel UniversityChao Wang - Drexel UniversityBiao Han - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, United StatesFeini Qu - University of PennsylvaniaHao Qi - Drexel UniversityChristopher Y. Li - Drexel UniversityRobert L. Mauck - University of PennsylvaniaLin Han - Drexel University
- Publication Details
- Journal of biomechanics, v 72
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000430889400033
- Scopus ID
- 2-s2.0-85044005142
- Other Identifier
- 991019169668604721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biophysics
- Engineering, Biomedical