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Journal article
Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation
Communications biology, v 7(1), 387
30 Mar 2024
PMID: 38553542
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Substance use disorders (SUDs) are highly comorbid with HIV infection, necessitating an understanding of the interactive effects of drug exposure and HIV. The relationship between HIV infection and cocaine use disorder is likely bidirectional, with cocaine use directly impacting immune function while HIV infection alters addiction-related behavior. To better characterize the neurobehavioral and immune consequences of HIV infection and cocaine exposure, this study utilizes a humanized mouse model to investigate the outcomes of HIV-1 infection on cocaine-related behaviors in a conditioned place preference (CPP) model, and the interactive effects of cocaine and HIV infection on peripheral and central nervous system inflammation. HIV infection selectively impairs cocaine CPP extinction without effecting reinstatement or cocaine seeking under conflict. Behavioral alterations are accompanied by immune changes in HIV infected mice, including increased prefrontal cortex astrocyte immunoreactivity and brain-region specific effects on microglia number and reactivity. Peripheral immune system changes are observed in human cytokines, including HIV-induced reductions in human TNFα, and cocaine and HIV interactions on GM-CSF levels. Together these data provide new insights into the unique neurobehavioral outcomes of HIV infection and cocaine exposure and how they interact to effect immune responses.
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Details
- Title
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation
- Creators
- Lauren A Buck - Drexel UniversityQiaowei Xie - Drexel UniversityMichelle Willis - Drexel UniversityChristine M Side - Drexel UniversityLaura L Giacometti - Drexel UniversityPeter J Gaskill - Drexel UniversityKyewon Park - University of PennsylvaniaFarida Shaheen - University of PennsylvaniaLili Guo - University of Nebraska Medical CenterSanthi Gorantla - University of Nebraska Medical CenterJacqueline M Barker - Drexel University
- Publication Details
- Communications biology, v 7(1), 387
- Publisher
- Springer Nature
- Grant note
- R33DA041018 / U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R03DA047919 / U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA054535 / U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DP2DA051907 / U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) P30MH092177 / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001195509800002
- Scopus ID
- 2-s2.0-85188998087
- Other Identifier
- 991021864117804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology