Journal article
Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells
Immunity & ageing, v 10(1), pp 36-36
19 Aug 2013
PMID: 23957960
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments with T cell receptor transgenic (TCR Tg) mice to study the impaired CD8 T cell response with aging.
Findings: After stimulation with a CD8 T cell epitope, HA518-524, the response of TCR Tg CD8 T cells from aged mice was decreased compared to the response of TCR Tg T cells from young mice. CD90 expression was also substantially decreased on the TCR Tg CD8 T cells of aged mice. However, the responses of CD90(hi) and CD90(low) CD8 T cells of the aged mice were similar in both early activation and proliferation, demonstrating that the impaired Tg T cell response with aging is not associated with the altered CD90 expression on CD8 T cells.
Conclusions: The impaired Tg CD8 T cell response in aged mice is not due to age-associated changes in CD90 expression on Tg CD8 T cells.
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Details
- Title
- Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells
- Creators
- Jiu Jiang - Drexel UniversityErin Fisher - Drexel UniversityDonna M. Murasko - Drexel University
- Publication Details
- Immunity & ageing, v 10(1), pp 36-36
- Publisher
- Springer Nature
- Number of pages
- 4
- Grant note
- AG14913 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Biology
- Web of Science ID
- WOS:000327237800002
- Scopus ID
- 2-s2.0-84882510655
- Other Identifier
- 991020950461604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Geriatrics & Gerontology
- Immunology