Journal article
Impersistence of depression in youth: Implications for drug study design
Journal of clinical pharmacology, v 46(9), pp 1044-1051
Sep 2006
PMID: 16920900
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Food and Drug Administration data show that most anti-depressant studies in youth do not show drug effect. The few positive studies used rigorous diagnostic screening procedures, suggesting major depressive disorder (MDD) may not be a persistent condition in a subgroup of youth. To investigate persistence of MDD, we serially assessed a cohort of inpatients admitted to the hospital with a clinical diagnosis of MDD. Assessments included a structured diagnostic interview, the Diagnostic Interview for Children and Adolescents-Revised (DICA-R), and measures of depressive symptomatology. Of 66 subjects (40 girls; mean age, 14.4 +/- 2.2 years), 34 (51.5%) met DICA-R criteria for MDD at the initial postadmission assessment. Of these, only 8 (23.5%) met DICA-R criteria for MDD at any subsequent assessment. Similar reductions were found on other ratings of depression. In conclusion, MDD did not persist in this sample. The findings suggest a multigated assessment procedure should be employed before randomization in antidepressant clinical trials.
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Details
- Title
- Impersistence of depression in youth: Implications for drug study design
- Creators
- Richard P Malone - Drexel UniversityDavid S Bennett - Drexel UniversityMary Anne Delaney - Drexel UniversityMuniya S Choudhury - Columbia UniversityJames F Luebbert - Wordsworth Academy in Ft. Washington, PennsylvaniaJacqueline Cater - Biomedical Statistical Consulting, Wynnewood, Pennsylvania
- Publication Details
- Journal of clinical pharmacology, v 46(9), pp 1044-1051
- Publisher
- Sage
- Grant note
- MH-00979 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry; [Retired Faculty]
- Web of Science ID
- WOS:000240092500011
- Scopus ID
- 2-s2.0-33747038950
- Other Identifier
- 991019168068404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy