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Journal article
Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies
Drug delivery and translational research, Vol.10(5), pp.1191-1202
01 Oct 2020
PMID: 32232681
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The retinal physiology can accrue oxidative damage and inflammatory insults due to age and metabolic irregularities. Two notable diseases that involve retinal and choroidal neovascularization are proliferative diabetic retinopathy and wet age-related macular degeneration. Currently, these diseases are mainly treated with anti-VEGF drugs (VEGF = vascular endothelial growth factor), generally on a monthly dosage scheme. We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce frequency of dosage and propose a path forward for improving patient outcomes. Graphical abstract Development of materials for long-term intravitreal delivery for management of posterior segment diseases.
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Details
- Title
- Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies
- Creators
- Biplab Sarkar - New Jersey Institute of TechnologyZain Siddiqui - New Jersey Institute of TechnologyKa Kyung Kim - New Jersey Institute of TechnologyPeter K Nguyen - New Jersey Institute of TechnologyXavier Reyes - New Jersey Institute of TechnologyTrevor J McGill - Oregon Health & Science UniversityVivek A Kumar - New Jersey Institute of Technology
- Publication Details
- Drug delivery and translational research, Vol.10(5), pp.1191-1202
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- R15 EY029504 / NEI NIH HHS IIP 1903617 / Directorate for Engineering
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991021956422704721
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- Domestic collaboration
- Web of Science research areas
- Instruments & Instrumentation
- Medicine, Research & Experimental
- Pharmacology & Pharmacy