Journal article
Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis
Ai zheng, v 30(9), pp 612-619
Sep 2011
PMID: 21880182
Abstract
Metastasis represents by far the most feared complication of prostate carcinoma and is the main cause of death for patients. The skeleton is frequently targeted by disseminated cancer cells and represents the sole site of spread in more than 80% of prostate cancer cases. Compatibility between select malignant phenotypes and the microenvironment of colonized tissues is broadly recognized as the culprit for the organ-tropism of cancer cells. Here, we review our recent studies showing that the expression of platelet-derived growth factor receptor alpha (PDGFRα) supports the survival and growth of prostate cancer cells in the skeleton and that the soluble fraction of bone marrow activates PDGFRα in a ligand-independent fashion. Finally, we offer pre-clinical evidence that this receptor is a viable target for therapy.
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15 citations in Scopus
Details
- Title
- Implication of platelet-derived growth factor receptor alpha in prostate cancer skeletal metastasis
- Creators
- Qingxin Liu - Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USADanielle JerniganYun ZhangAlessandro Fatatis
- Publication Details
- Ai zheng, v 30(9), pp 612-619
- Publisher
- England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; Civil, Architectural, and Environmental Engineering
- Scopus ID
- 2-s2.0-80053091666
- Other Identifier
- 991014878301404721