Journal article
Importance of Microminerals for Maintaining Antioxidant Function After COVID-19-induced Oxidative Stress
Reports of biochemistry and molecular biology, v 11(3), pp 479-486
01 Oct 2022
PMID: 36718301
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: COVID-19 is caused by the Severe Acute Respiratory Distress Syndrome Coronavirus 2. Since the antioxidant mechanisms such as glutathione peroxidase or superoxide dismutase are downregulated during infection by the virus, there is an imbalance in the oxidant-antioxidant system. In this study we aimed to identify the effect of COVID-19 on the antioxidant defense mechanism by comparing the concentrations of antioxidants and microminerals in COVID-19 patients and healthy controls.Methods: This cross-sectional analytical study involved 200 patients at Kasturba Hospital, Manipal University. The serum concentrations of antioxidants and minerals were determined to establish the impact of COVID-19 on antioxidants mechanism and nutrient status in COVID-19 patients.Results: The serum concentrations of GPX (10.36 & PLUSMN; 2.70 > 5.82 & PLUSMN; 1.64 mKAT/L, p < 0.0001) and copper (2192.5 & PLUSMN; 449.8 > 782.15 & PLUSMN; 106.5 mu g/dL, p < 0.0001) were significantly greater, and zinc (34.78 & PLUSMN; 4.5 & LE; 81.07 & PLUSMN; 10.13 mu g/dL, p < 0.0001) was significantly less, in the study group than in controls. The Pearson correlation between serum SOD and zinc was significant (r = 0.491, p < 0.0001) indicating the importance of zinc in maintaining and improving SOD activity. No significant correlations were observed between copper and SOD (r =-0.089) or iron and CAT (r =-0.027).Conclusions: Our study demonstrated the expected increase in oxidant-radical production during COVID-19 by estimating the altered concentrations of antioxidants and the minerals required to neutralize the elevated ROS. This finding is not novel but adds to the existing literature, which recommends nutritional supplementation of microminerals and antioxidants.
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Details
- Title
- Importance of Microminerals for Maintaining Antioxidant Function After COVID-19-induced Oxidative Stress
- Creators
- Ravindra Maradi - College Station Medical CenterVivek Joshi - Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Innovat Way, Wyomissing, PA 19610 USAVaideki Balamurugan - College Station Medical CenterDivya Susan Thomas - College Station Medical CenterManjunath B. Goud - College Station Medical CenterDepartment of Biochemistry and Molecular Biology, Drexel University college of Medicine, Innovation Way, Wyomissing, 19610, Pennsylvania, USA
- Publication Details
- Reports of biochemistry and molecular biology, v 11(3), pp 479-486
- Publisher
- Varastegan Inst Medical Sciences
- Number of pages
- 8
- Grant note
- PGR587 / Kasturba Medical College, Manipal Academy of Higher Education, India
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000913873300015
- Scopus ID
- 2-s2.0-85146664366
- Other Identifier
- 991021229892104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology