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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Importance of pulsatility in hypertensive carotid artery growth and remodeling
Journal of hypertension, v 27(10), pp 2010-2021
Oct 2009
PMID: 19584753
Abstract
Arteries experience marked variations in blood pressure and flow during the cardiac cycle that can intensify during exercise, in disease, or with aging. Diverse observations increasingly suggest the importance of such pulsatility in arterial homeostasis and adaptations. We used a transverse aortic arch banding model to quantify chronic effects of increased pulsatile pressure and flow on wall morphology, composition, and biaxial mechanical properties in paired mouse arteries: the highly pulsatile right common carotid artery proximal to the band (RCCA-B) and the nearly normal left common carotid artery distal to the band (LCCA-B). Increased pulsatile mechanical stimuli in RCCA-B increased wall thickness compared with LCCA-B, which correlated more strongly with pulse (r* = 0.632; P < 0.01) than mean (r* = 0.020; P = 0.47) or systolic (r* = 0.466; P < 0.05) pressure. Similarly, inner diameter at mean pressure increased in RCCA-B and correlated slightly more strongly with a normalized index of blood velocity pulsatility (r* = 0.915; P < <0.001) than mean flow (r* = 0.834; P < 0.001). Increased wall thickness and luminal diameter in RCCA-B resulted from significant increases in cell number per cross-sectional area (P < 0.001) and collagen-to-elastin ratio (P < 0.05) as well as a moderate (1.7-fold) increase in glycosaminoglycan content, which appears to have contributed to the significant decrease (P < 0.001) in the in-vivo axial stretch in RCCA-B compared with LCCA-B. Changes in RCCA-B also associated with a signficant increase in monocyte chemoattractant protein-1 (P < 0.05) whereas LCCA-B did not. Pulsatile pressure and flow are thus important stimuli in the observed three-dimensional arterial adaptations, and there is a need for increased attention to the roles of both axial wall stress and adventitial remodeling.
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Details
- Title
- Importance of pulsatility in hypertensive carotid artery growth and remodeling
- Creators
- John F Eberth - Texas A&M UniversityVincent C Gresham - Texas A&M UniversityAnilkumar K Reddy - Baylor College of MedicineNatasa Popovic - Texas A&M UniversityEmily Wilson - Texas A&M UniversityJay D Humphrey - Texas A&M University
- Publication Details
- Journal of hypertension, v 27(10), pp 2010-2021
- Publisher
- Lippincott
- Grant note
- R01 HL022512 / NHLBI NIH HHS P41 EB002182 / NIBIB NIH HHS R01 HL064372 / NHLBI NIH HHS P41 RR011795 / NCRR NIH HHS HL-64372 / NHLBI NIH HHS R01 HL064372-05 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000270543300014
- Scopus ID
- 2-s2.0-70350446656
- Other Identifier
- 991021902594004721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Peripheral Vascular Disease