Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Improved Ethical Guidance for the Return of Results from Psychiatric Genomics Research
Molecular psychiatry, v 23(1), pp 15-23
21 Nov 2017
PMID: 29158581
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is an emerging consensus that genomic researchers should, at a minimum, offer to return to individual participants clinically valid, medically important, and medically actionable genomic findings (e.g., pathogenic variants in
BRCA1
) identified in the course of research. However, this is not a common practice in psychiatric genetics research. Furthermore, psychiatry researchers often generate findings that do not meet all of these criteria, yet there may be ethically compelling arguments to offer selected results. Here, we review the return of results debate in genomics research and propose that, as for genomic studies of other medical conditions, psychiatric genomics researchers should offer findings that meet the minimum criteria stated above. Additionally, if resources allow, psychiatry researchers could consider offering to return pre-specified “clinically valuable” findings even if not medically actionable – for instance, findings that help corroborate a psychiatric diagnosis, and findings that indicate important health risks. Similarly, we propose offering “likely clinically valuable” findings, specifically, variants of uncertain significance potentially related to a participant’s symptoms. The goal of this Perspective is to initiate a discussion that can help identify optimal ways of managing the return of results from psychiatric genomics research.
Metrics
Details
- Title
- Improved Ethical Guidance for the Return of Results from Psychiatric Genomics Research
- Creators
- Gabriel Lázaro-Muñoz - Baylor College of MedicineMartilias S Farrell - University of North Carolina at Chapel HillJames J Crowley - Karolinska InstituteDawn M Filmyer - Translational Neuroscience LLC, Conshohocken, USARita A Shaughnessy - Drexel UniversityRichard C Josiassen - Product Innovation and Engineering (United States) (United States, Saint James) - LLCPatrick F Sullivan - Karolinska Institute
- Publication Details
- Molecular psychiatry, v 23(1), pp 15-23
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000423441000004
- Scopus ID
- 2-s2.0-85040037561
- Other Identifier
- 991019167782204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- Psychiatry