Journal article
Improved Lipid Target Level Attainment in Patients with Peripheral Artery Disease
CURRENT VASCULAR PHARMACOLOGY, v 19(6), pp 634-642
2021
PMID: 33430734
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Patients with peripheral artery disease (PAD) fall under the category of a very high cardiovascular risk. Although consequent lipid-lowering therapy (LLT) is advised, only sparse data on attained target level in PAD exists. Objectives: We aimed to analyse contemporary guideline recommendations for LLT in symptomatic PAD patients. Methods: A monocentric, prospective, observational study involving 200 symptomatic PAD patients was conducted. Guideline target level attainment and LLT were analysed between 2017 and 2019. Results: Overall, 78.5% of the patients were on statin therapy, mainly of high intensity, with atorvastatin in 50% and rosuvastatin in 33% of the cases. The average statin dosage adjusted for simvastatin was 55 mg/d. Low density lipoprotein-cholesterol (LDL-C) was <1.8 mmol/L in 53% and <1.4 mmol/L in 34% of the cases. Mean LDL-C levels were at 1.85 +/- 0.88 mmol/L. We observed no difference in the treatment and the target level attainment of patients with a stable PAD (intermittent claudication) or chronic critical PAD. However, patients with >= 1 vascular region affected (i.e., coronary and/or cerebrovascular) were treated more intensively and had lower LDL-C levels than patients with PAD alone. Conclusion: It appears that there are more awareness and improvement of previously documented undertreatment of LDL-C levels in symptomatic PAD patients. Although statin treatment is initiated in the majority of patients, our findings call for a continuously intensified LLT in symptomatic PAD patients.
Metrics
1 Record Views
Details
- Title
- Improved Lipid Target Level Attainment in Patients with Peripheral Artery Disease
- Publication Details
- CURRENT VASCULAR PHARMACOLOGY, v 19(6), pp 634-642
- Publisher
- BENTHAM SCIENCE PUBL LTD; SHARJAH
- Number of pages
- 8
- Grant note
- This study was supported by AMGEN with project-related funding.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000724565500005
- Scopus ID
- 2-s2.0-85122487688
- Other Identifier
- 991021860765604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Peripheral Vascular Disease
- Pharmacology & Pharmacy