Logo image
Back
Improvement in relapse recovery with peginterferon beta-1a in patients with multiple sclerosis
Journal article   Open access

Improvement in relapse recovery with peginterferon beta-1a in patients with multiple sclerosis

Thomas F Scott, Bernd C Kieseier, Scott D Newsome, Douglas L Arnold, Xiaojun You, Serena Hung and Bjoern Sperling
Multiple sclerosis journal - experimental, translational and clinical, v 2, pp 205521731667664-2055217316676644
Jan 2016
DOI: https://doi.org/10.1177/2055217316676644
PMID: 28607743
url
https://doi.org/10.1177/2055217316676644View
Published, Version of Record (VoR)CC BY-NC V4.0,  Open

Abstract

Background Subcutaneous peginterferon beta-1a every 2 weeks significantly affects clinical outcomes in patients with relapsing–remitting multiple sclerosis (RRMS). Objectives To explore relationships between relapses and worsening of disability in patients with RRMS, and assess the treatment effect of peginterferon beta-1a on relapse recovery. Methods Post-hoc analysis of the 2-year, randomized, double-blind, parallel-group, Phase 3 ADVANCE study. The severity of relapses, proportion of patients with relapses associated with residual disability (onset of 24-week confirmed disability progression (CDP) within 90 days following a relapse), and persistence of changes in Functional Systems Scores, were compared between treatment groups. Results Subcutaneous peginterferon beta-1a every 2 weeks significantly reduced the proportion of patients experiencing relapse associated with CDP over 2 years (6.6%, compared with 15.1% of patients who received placebo in Year 1; p = 0.02). Reduction in relapses associated with residual disability was greater than the treatment effect on overall relapse rate, and occurred despite similar relapse severity across treatment groups. Conclusions The beneficial effect of peginterferon beta-1a on risk of CDP may be attributable to the combination of an overall reduction in the risk of relapses and improvement in recovery from relapses, thus limiting further disability progression. Trial registration ClinicalTrials.gov identifier: NCT00906399

Metrics

9 Record Views
12 citations in Scopus

Details

Logo image